细胞色素氧化酶P4501A1基因多态性与中国西南地区汉族人群慢性阻塞性肺疾病易感相关性的研究  

Comparative Study of Cytochrome P4501A1 Gene Polymorphism and Susceptibility to Chronic Obstructive Pulmonary Disease

作　　者：王晓珍[1] 杨小东[1] 刘蔺[1] 黄娜[1] 刘丹[1] 袁泉[1] 

机构地区：[1]四川大学华西医院呼吸内科,四川成都610041

出　　处：《华西医学》2008年第6期1316-1318,共3页West China Medical Journal

摘　　要：目的:探讨中国西南地区汉族人群细胞色素氧化酶P4501A1(CYP1A1)基因多态性与慢性阻塞性肺疾病(COPD)易感性和肺功能损害程度的关系。方法:应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析的方法分别对年龄、性别、吸烟史匹配的115例COPD患者和94例健康对照者的外显子7上rs1048943和内含子1上rs4646421的基因多态性进行检测。结果:115例COPD患者外显子7rs1048943位点A/A、A/G、G/G3种基因型的分布频率分别是39.1%,53.1%,7.8%,而对照组分别为56.4%,39.4%,4.2%,两组比较差异有统计学意义(P<0.05)。内含子1上rs4646421位点C/C、C/T、T/T3种基因型的分布频率分别为27.0%,51.3%,21.7%;而对照组这三个基因型的分布频率分别为24.5%,53.2%,22.3%,两组比较差异无统计学意义(P>0.05)。肺功能正常者即对照组与COPDⅠ级患者、COPDⅠ级与Ⅱ级患者、COPDⅡ级与Ⅲ级患者、COPDⅢ级与Ⅳ级患者之间基因型分布进行比较,rs1048943位点P值分别为0.294,0.718,0.052,0.405;rs4646421位点P值分别为0.808,0.366,0.301,0.356。结论:CYP1A1外显子7rs1048943位点基因多态性可能与中国西南地区汉族COPD患者的发病有关。Objective:To investigate whether polymorphism in gene for cytochrome P4501A1 has any bearing on individal susceptibility to the development of chronic obstructive pulmonary disease(COPD).Methods:The genotypes of 115 patients with COPD and 94 healthy smoking subjects as controls were tested with polymerase chain reaction followed by restriction fragment length polymorphism analysis for CYP1A1 gene.Results:In COPD group,the frequencies of the seventh exon rs1048943 locus genotypes AA,AG and GG were respective...

关 键 词：慢性阻塞性肺疾病 细胞色素氧化酶P4501A1 易感性 

分 类 号：R563.9[医药卫生—呼吸系统]