甲基苯丙胺诱导实验大鼠神经毒性及噻萘普汀保护的研究  

The Toxicity of Methamphetamine and the Protection of Tianeptine

作　　者：祝三平[1] 王雪[2] 黄明生[2] 

机构地区：[1]四川大学研究生院 [2]四川大学华西医院精神科,四川成都610041

出　　处：《华西医学》2008年第6期1365-1366,共2页West China Medical Journal

摘　　要：目的:探讨甲基苯丙胺的神经毒性及噻萘普汀的保护机制。方法:设立对照组(b)和实验组(a、c),a组腹腔注射甲基苯丙胺;c组在予甲基苯丙胺前7天予噻萘普汀;b组注射等体积生理盐水。实验后采用苏木精-伊红染色,光镜观察;TUNEL法检测凋亡。结果:甲基苯丙胺可损害神经元的轴突、树突,并诱导凋亡。结论:甲基苯丙胺通过诱导凋亡,引起神经毒性;预先予噻萘普汀具保护效应。Objective:To investigate the neurotoxicity of methamphetamine and the neuro-protection of tianeptine.Methods:An acute toxic dosing model in rat was established by intraperitoneal injection of methamphetamine,and some rats were treated with tianeptine seven days before.The brain tissues were observed with light microscope after HE staining;apoptosis was detected by TUNEL.Results:Methamphetamine might damage the brain and induce apoptosis,pretreatment with tianeptine could block apoptosis.Conclusion:Methamphe...

关 键 词：甲基苯丙胺 神经毒性 噻萘普汀 

分 类 号：R964[医药卫生—药理学]