人巨细胞病毒对兔平滑肌细胞LOX-1表达的影响  

Human cytomegalovirus infection up-regulates expression of LOX-1 in rabbit smooth vascular muscle cells

作　　者：雷雪明[1] 李树英[1] 董波[2] 彭莹[1] 唐伟[1] 齐眉[1] 刘娟[1] 孙允东[1] 于晗[1] 周亚滨[1] 

机构地区：[1]山东大学医学院微生物学教研室,济南250012 [2]山东大学附属省立医院心内科,济南250012

出　　处：《山东大学学报（医学版）》2009年第2期6-9,共4页Journal of Shandong University:Health Sciences

摘　　要：目的了解人巨细胞病毒(HCMV)感染对兔平滑肌细胞(SMC)凝集素样氧化型低密度脂蛋白受体-1(LOX-1)表达的影响,探讨HCMV在动脉粥样硬化(AS)发生发展中的可能作用机制。方法采用RT-PCR、Western blotting等技术检测HCMV ADl69株感染的兔SMC中LOX-1的表达。结果HCMV感染兔SMC后,LOX-1表达明显升高(P<0.01)。结论HCMV可引起兔SMC中LOX-1的表达上调,这可能是HCMV参与AS的机制之一。Objective To investigate the effect of human cytomegalovirus(HCMV) infection on expression of lectin-like oxidized low-density lipoprotein receptor-1 in rabbit smooth vascular muscle cells,and to show its role in the formation of atherosclerosis(AS).Methods Expression of LOX-1 in rabbit smooth vascular muscle cells which were affected by HCMV ADl69 was analyzed by reverse transcription-polymerase chain reaction and Western blotting.Results HCMV infection up-regulated the expression of LOX-1 in rabbit smooth...

关 键 词：巨细胞病毒 受体 脂蛋白 平滑肌细胞 

分 类 号：R373[医药卫生—病原生物学]