辛伐他汀对冠心病患者血清IL-6和IL-10的影响  

Effects of Simvastatin on Plasma Levels of IL-6 and IL-10 in Patients with Coronary Heart Disease

作　　者：李响[1] 刘成[2] 王璟璐[1] 刘玉婷[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院心内科,黑龙江哈尔滨150080 [2]哈尔滨医科大学第四临床医学院,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2009年第2期101-102,155,共3页Heilongjiang Medical Journal

摘　　要：目的分析冠心病患者(CHD)外周血中白介素-6(IL-6)和白介素-10(IL-10)的含量变化及辛伐他汀对其的影响。方法冠心病患者分为常规治疗(R)组和常规加辛伐他汀治疗(R+S)组,分别于治疗前及治疗后2周取外周血,健康对照(C)组仅采血1次。ELISA试剂盒测定IL-6和IL-10的含量,直接法测定低密度脂蛋白胆固醇,比浊法测高敏C-反应蛋白(CRP)。结果辛伐他汀治疗前,R组和R+S组患者血浆中IL-6I、L-10和CRP水平均高于C组。治疗后,R+S组患者血浆中IL-6和CRP含量降低,IL-10含量增加;R组治疗前后IL-6、IL-10和CRP水平均无明显差异。各组治疗前后低密度脂蛋白水平均无明显差异。结论CHD患者处于免疫活化状态;他汀能够抑制炎症反应,该作用独立于其降脂作用之外,是其抗动脉粥样硬化的机制之一。Objective To investigate the variation of plasma inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in patients with coronary heart disease(CHD) and the effects of simvastatin on it.Methods 32 patients with CHD were divided into two groups:16 treated with simvastatin(10 mg/d) and 16 not treated with simvastatin.Plasma levels of IL-6 and IL-10 were detected by ELISA.C-reactive protein(CRP) was detected by turbidimetry.Results When compared with normal group,significantly increased levels of IL-6...

关 键 词：冠心病 白介素-6(IL-6) 白介素-10(IL-10) 辛伐他汀 

分 类 号：R541.4[医药卫生—心血管疾病]