潍坊地区汉族人群PON1(对氧磷酶)Q192R基因多态性与冠心病的相关性研究  

Study on PON1 Gene Polymorphism and Association of PON1 polymorphism With Coronary Heart Disease among Chinese Han Population of Weifang District

作　　者：邢旭东[1] 刘焕荣[1] 翟振道[1] 秦浩[2] 季祥武[2] 

机构地区：[1]山东省昌邑市人民医院,261300 [2]潍坊医学院

出　　处：《中国误诊学杂志》2009年第5期1012-1014,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:测定PON1(对氧磷酶)Q192R基因多态性及在人群中的分布,分析各基因型与冠心病的关系。方法:冠心病患者128例,男80例,女48例,年龄为36~82(65.25±9.83)岁,全部病例有明确心梗病史或经冠状动脉(冠脉)造影确诊。正常对照组110例,男66例,女44例,年龄31~87(63.52±7.91)岁,选自人群健康查体的随机个体。结果:PON1Q192R有QQ、QR、RR三种基因型,正常人的基因型频率分别为0.200 0、0.490 9、0.309 1,冠心病组QQ、QR、RR三种基因频率分别为0.226 6、0.531 3、0.242 1。结论:潍坊地区汉族人群PON1(对氧磷酶)基因多态性和冠心病无关。Objective:To investigate the distribution of the Q/R polymorphism of PON1 gene in Chinese Han nationality and to analyze the association of PON1 gene with coronary atherosclerotic heart disease(CHD).Methods:128 patients with CHD (80men and 48 women,mean age 65.25±9.83 years) and 110 unrelated health individuals(66men and 44 women,mean age 63.52±7.919 years) were studied.ALL patients had the history of MI or were confirmed by coronary angiography.There was no relationship between individuals in the study pop...

关 键 词：芳基二烷基磷酸酶/遗传性 多态现象 遗传 冠状动脉疾病/酶学 人类 山东 

分 类 号：R541.4[医药卫生—心血管疾病]