过敏性紫癜患儿GPⅡb/Ⅲa、P-选择素及vWF检测的意义  

Effect of GPⅡb/Ⅲa,P-Selectin and vWF in children with Henoch-Schonlein purpura

作　　者：张洪霞[1] 刘雪梅[2] 柳方娥[1] 林爱伟[2] 段春红[2] 杨晓梅[2] 

机构地区：[1]山东大学第二医院儿科,济南250033 [2]山东大学齐鲁儿童医院,济南250022

出　　处：《山东大学学报（医学版）》2009年第1期64-67,共4页Journal of Shandong University:Health Sciences

摘　　要：目的检测过敏性紫癜(HSP)患儿全血中血小板膜糖蛋白GPⅡb/Ⅲa(CD41a/CD61)、P-选择素(CD62P)及血浆中血管性假血友病因子(vWF)的表达水平,探讨它们在HSP发病机制中的作用。方法应用流式细胞仪和酶联免疫吸附试验(ELISA)分别检测HSP患儿(急性期44例,缓解期40例)及健康对照儿童(18例)空腹血CD41a/CD61、CD62P及vWF水平。结果HSP患儿急性期CD41a/CD61、CD62P、vWF水平明显高于缓解期和对照组(P均<0.01);肾受累组CD41a/CD61、CD62P、vWF水平高于非肾受累组(P<0.01)。结论血小板的活化及血管内皮的损伤在HSP的发病机制中起着重要作用,CD41a/CD61、CD62Pv、WF水平的测定有助于了解HSP患儿早期的凝血异常,为抗凝治疗提供依据。Objective To investigate the role of platelet membrane glycoproteinⅡb/Ⅲa,P-selectin and von Willebrane Factor in children with Henoch-Schonlein purpura(HSP),and to investigate the pathological role of them in HSP.Methods The concentrations of CD41a/CD61 and CD-62P were determined by flow cytometry and the level of vWF by an enzyme-linked immunosorbent assay(ELISA) method in 44 patients with acute HSP,40 patients in the recovery phase and 18 healthy controls.Results The plasma levels of CD41a/CD61,CD-62P and...

关 键 词：紫癜 过敏性 血小板膜糖蛋白类 P-选择素 血管性假血友病因子 儿童 

分 类 号：R725.5[医药卫生—儿科]