普卢利沙星的吸附伏安特性及其应用  

Adsorptive voltammetric behavior of prulifloxacin and its application

作　　者：祝保林[1] 高锦红[1] 李吉峰[1] 

机构地区：[1]渭南师范学院化学化工系,陕西渭南714000

出　　处：《山东大学学报（医学版）》2009年第1期98-102,105,共6页Journal of Shandong University:Health Sciences

基　　金：陕西省教育厅专项科研计划项目资助课题(06JK303);陕西省科技厅专项基金(2006B25)

摘　　要：目的探讨普卢利沙星的吸附伏安特性。方法在0.3 mol.L-1KH2PO4-Na2HPO4(pH6.40)底液中,普卢利沙星(prulifloxacin,PLF)在汞电极上有一线性扫描还原峰,峰电位EP=-1.02 V(vsAg/AgCl),该峰具有明显的吸附性。结果吸附粒子为PLF中性分子,测得PLF在汞电极上的饱和吸附量Γs=4.01×10-11mol.cm-2,每个PLF分子所占电极面积为2.02 nm2,PLF在汞电极上的吸附符合Langmuir吸附等温式;测得吸附系数β=1.08×106,25℃时的吸附自由能ΔGθ=-29.14 kJ.mol-1,电极反应电子数n=2,不可逆体系动力学参量αna=1.01,表面电极反应速率常量ks=0.27 s-1。结论建立了吸附溶出伏安法测定PLF的最佳条件,方法的检出限为2.0×10-8mol.L-1。Objective To explore the Adsorptive Voltammetric Behavior of Prulifloxacin.Methods In a supporting electrolyte of 0.3 mol·L-1KH2PO4NaH2PO4(pH6.4),a reduction peac of Prulifloxacin(PLF) with a potential of-1.02 V(vs Ag/AgCL) and adsorptive characteristics were observed by linear sweep voltammetry at the Hg electrode.Results The adsorbed species were most probably the neutral molecules of PLF.The saturated adsorption amount of 4.01×10-11mol·cm-2 and an area occupied by each molecule of 2.02 nm2 at Hg electrod...

关 键 词：普卢利沙星 吸附溶出伏安法 电化学行为 药物分析 

分 类 号：R927[医药卫生—药学]