注射用清开灵冻干粉体内抗菌活性研究  

Study on Anti-bacterial Activity of Qingkailing Freeze-Dried Powder for Injection in vivo

作　　者：李东[1] 黄继华[2] 张淑华[3] 杨芳炬[2] 

机构地区：[1]乐山职业技术学院,四川乐山614000 [2]四川大学华西医学中心,四川成都610041 [3]四川抗菌素工业研究所,四川成都610051

出　　处：《现代中药研究与实践》2009年第1期53-55,共3页Research and Practice on Chinese Medicines

摘　　要：目的研究注射用清开灵冻干粉对临床分离致病菌的体内抗菌活性。方法注射用清开灵冻干粉与市售清开灵注射液作比较,建立小鼠细菌感染模型,测定注射用清开灵冻干粉浓缩液对金葡菌、大肠埃希菌感染小鼠的ED50,观察注射用清开灵冻干粉体内抗菌活性。结果注射用清开灵冻干粉对金葡菌、大肠埃希菌感染小鼠的ED50以生药剂量计分别为7.40g/kg、7.54g/kg,具有一定的体内抗菌活性。结论注射用清开灵冻干粉对金葡菌、大肠埃希菌感染小鼠均具有保护作用。Objective To study the anti-bacterial activity of Qingkailing Freeze-Dried Powder for Injection(QI) in vivo.Methods The mice models were divided into the medicine-given group, the positive-control group and the negative-control group.The medicine-given group was administrated by QI and Qingkailing Injection on sale.The positive-control group was administrated by Ceftriaxone and negative-control group 0.9% NS.The three groups were infected with injection of Staphylococcus aureus and Escherichia coli suspensi...

关 键 词：注射用清开灵冻干粉 金黄色葡萄球菌 大肠埃希菌 ED50 

分 类 号：R285[医药卫生—中药学]