上气道变应炎症对下气道的影响  

Effects of upper airway allergic inflammation on the lower airway

作　　者：徐定远[1] 李泽卿[1] 吴波[2] 张勇[1] 季俊峰[1] 薛飞[1] 王秋萍[1] 

机构地区：[1]南京军区总医院耳鼻咽喉科,南京210002 [2]南京军区总医院病理科,南京210002

出　　处：《山东大学耳鼻喉眼学报》2009年第1期57-59,67,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：江苏省博士后基金资助课题(0801030B)

摘　　要：目的通过豚鼠实验模型研究上气道变应性炎症对下气道的影响。方法12只豚鼠分为2组,每组6只,鼻炎组豚鼠给予鼻腔卵蛋白/氢氧化铝滴注(连续10 d,每天2次)。间隔1周后,鼻腔给予2%卵蛋白每日滴注,连续7 d;对照组均使用生理盐水替代卵蛋白。最后一次激发后10 min,对喷嚏、抓鼻、流涕等症状量化评估,观察肺部症状;抽取动物血清,ELISA方法测定IgE和IL-5水平;计量鼻腔黏膜及肺部黏膜嗜酸粒细胞浸润数量,观察鼻腔和肺组织的病理改变。结果鼻炎组豚鼠明显出现喷嚏、鼻痒、挠鼻、流涕等典型症状,但肺部哮喘症状不明显;血清IgE、IL-5水平升高;鼻腔和肺部黏膜见多量嗜酸粒细胞浸润,且出现病理结构变化。对照组未出现上述变化。结论上气道变应性炎症可导致下气道发生类似的炎症反应,并导致免疫学改变。Objective To observe pathological and immunological changes of the lower airway in intranasal ovabumin induced animal models of allergic rhinitis in guinea pigs.Methods 12 Hartley guinea pigs(250-300 g) were randomly divided into two groups(the control group and the allergen exposure group).Guinea pigs were intranasally sensitized with ovalbumin absorbed on aluminum hydroxide twice a day for 10 days,and after one week they were challenged with 2% ovalbumin solution once every day for a total of 7 times.The ...

关 键 词：鼻炎 变应性炎症 联合气道 豚鼠 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]