头孢美唑对产ESBLs肠杆菌科细菌的体外抗菌作用研究  

In vitro activity of cefmetazole against extended spectrum β-lactamases producing Enterobacteriaceae isolates

作　　者：朱德妹[1] 吴湜[1] 吴培澄[1] 胡付品[1] 叶信予[1] 吴卫红[1] 郭燕[1] 张婴元[1] 

机构地区：[1]复旦大学附属华山医院抗生素研究所,上海200040

出　　处：《中国感染与化疗杂志》2009年第1期1-9,共9页Chinese Journal of Infection and Chemotherapy

摘　　要：目的评价头孢美唑对产ESBLs肠杆菌科细菌的体外抗菌活性。方法采用琼脂稀释法测定头孢美唑对临床分离大肠埃希菌、肺炎克雷伯菌、产酸克雷伯菌和奇异变形杆菌523株的体外抗菌作用。结果523株细菌中产ESBLs294株、产AmpC酶7株、同时产ESBLs和AmpC酶40株,非产ESBLs和AmpC酶182株。头孢美唑对上述4种肠杆菌科细菌中产ES-BLs菌株和非产ESBLs菌株均具有良好的抗菌作用,并较头孢西丁强2～4倍,但较头孢米诺为差。头孢美唑对ESBLs高度稳定,但对AmpC酶稳定性差,产AmpC酶菌株对其多呈现耐药。头孢美唑对产ESBLs菌株的作用优于受试的半合成青霉素,第一、第二、第三和第四代头孢菌素,亦优于氨苄西林-舒巴坦、头孢哌酮-舒巴坦和哌拉西林-他唑巴坦,但差于亚胺培南、美罗培南和帕尼培南;较受试的氨基糖苷类和氟喹诺酮类抗菌药略强或相仿。结论头孢美唑对ESBLs稳定,对产ESBLs菌株和非产ESBLs菌株均具有良好的抗菌作用。提示该药是治疗产ESBLs肠杆菌科细菌所致感染的可选药物之一。Objective To evaluate the in vitro antimicrobial activity of cefmetazole against extended spectrum β-lactamases(ESBLs)producing Enterobacteriaceae isolates.MethodsA total of 523 strains of E.coli,K.pneumoniae,K.oxytoca and P.mirabilis were isolated from clinical specimens.Antimicrobial susceptibility testing was done by agar dilution method.The results were assessed according to the Clinical and Laboratory Standards Institute(CLSI)and compared with selected antimicrobial agents.ResultsOf the 523 strains tes...

关 键 词：头孢美唑 超广谱Β内酰胺酶 革兰阴性杆菌 敏感性试验 

分 类 号：R96[医药卫生—药理学]