干扰素γ基因内含子1+874位点多态性与复发性尖锐湿疣的关系  

Relationship between Genetic Polymorphisms of Interferon-gamma Gene Intron 1+874 Site and Recurrent Condyloma Acuminata

作　　者：陆轶凡[1] 左亚刚[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730

出　　处：《中国医学科学院学报》2009年第1期3-5,共3页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(30740025);高等学校博士学科点专项科研基金(20070023066)~~

摘　　要：目的研究干扰素γ(IFN-γ)基因内含子1+874位点多态性与复发性尖锐湿疣(CA)的关系。方法采用序列特异性引物-聚合酶链反应(PCR-SSP)技术检测76例复发性CA患者(CA组)与80名正常对照者(对照组)IFN-γ基因内含子1+874位点的T/A单核苷酸多态性。结果CA组IFN-γ基因1+874位点基因型TT、TA、AA频率分别为10.5%、34.2%、55.3%,对照组分别为7.5%、30.0%、62.5%,两组间差异无显著性(χ2=0.959,P=0.619)。结论IFN-γ基因内含子1+874位点多态性与复发性CA无关。Objective To explore the relationship between the polymorphisms of interferon-gamma(IFN-γ) gene intron 1 at position +874 and Condyloma Acuminata(CA).Methods IFN-γ gene single nucleotide polymorphisms(intron 1 at position +874) were detected in 156 subjects,including 76 patients with recurrent CA(CA group) and 80 healthy controls(control group),by polymerase chain reaction with sequence specific primers.Results No significant difference of IFN-γ 1+874 was found between CA group(TT,TA,and AA frequencies were...

关 键 词：人乳头瘤病毒 尖锐湿疣 干扰素γ基因 基因多态性 易感性 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]