脓疱疮患儿鼻腔与皮损分离金黄色葡萄球菌的同源性  

Homology of Staphylococcus aureus Isolated from Skin Lesions and Nose of Patients with Impetigo

作　　者：李云珠[1] 马琳[1] 孔繁荣[2] 

机构地区：[1]首都医科大学附属北京儿童医院皮肤科,北京100045 [2]悉尼大学威斯敏医院临床病理学和医学研究所传染性疾病和微生物学中心

出　　处：《中国医学科学院学报》2009年第1期10-12,共3页Acta Academiae Medicinae Sinicae

基　　金：北京市自然科学基金(7062023,7092031);北京市优秀人才项目(20051A0300823)~~

摘　　要：目的研究脓疱疮患儿鼻腔与皮损金黄色葡萄球菌(SA)分离株的同源性。方法以2005年8月~2006年11月在北京儿童医院皮肤科就诊的263例患儿为研究对象,对其鼻腔和皮损分离物进行SA培养。随机选择58例鼻腔SA阳性患儿,对其鼻腔分离株和皮损分离株进行spa分型,使用相关专业网站对spa分型结果进行分析,研究鼻腔和皮损SA分离株的同源性。结果263例患儿中,106例为脓疱疮患儿,其中83例(78.3%)鼻腔SA阳性;157例为非脓疱疮患儿,其中33例(21.0%)鼻腔SA阳性;两组相比差异有显著性(P<0.01)。两组患儿鼻腔SA阳性者的年龄主要集中在1~6岁。106例脓疱疮患儿中,30例皮损初发于面部,其中28例(93.3%)鼻腔SA阳性;76例皮损初发于其他部位,其中56例(73.7%)鼻腔SA阳性;两者相比差异也有显著性(P<0.01)。spa分型结果显示,在30例脓疱疮患儿鼻腔和皮损SA分离株的对比中,有26例具有相同spa分型。结论脓疱疮患儿皮损和鼻腔分离的SA间存在较高的同源性,鼻腔SA携带与脓疱疮的发生可能密切相关。Objective To investigate the homology of Staphylococcus aureus(SA) strains isolated from nose and skin lesions of impetigo children.Methods Totally 263 outpatients aged 3 months to 14 years who were seen by the Department of Dermatology of Beijing Children s Hospital between August 2005 and March 2006 were enrolled in this study.The isolations from nose and skin lesions of 58 impetigo children who were randomly selected from these 263 children with spa sequence were typed.The sequence results of SA were ana...

关 键 词：脓疱疮 金黄色葡萄球菌 鼻腔定植 spa分型 

分 类 号：R753.1[医药卫生—皮肤病学与性病学]