骨灵片对骨质疏松大鼠骨形态计量学的影响研究  

Effects of Gu Ling Pianon histomorphometry on osteoporosis rats

作　　者：黄少慧[1] 张娟[1] 李娟[1] 蔡红兵[1] 李欣[1] 

机构地区：[1]南方医科大学

出　　处：《中国中医药现代远程教育》2008年第9期1011-1012,共2页Chinese Medicine Modern Distance Education of China

摘　　要：目的观察补肾中药骨灵片对去卵巢大鼠腰椎的骨形态计量学及生物力学影响,进一步探讨骨灵片治疗骨质疏松症的机理。方法选择3月龄SD大鼠36只,分为空白对照组(即假手术组,A组)、去卵巢组(B组)、骨灵片低(C组)、中(D组)、高剂量组(E组)、雌激素组(F组),每组各6只。分别给予生理盐水、骨灵片高、中、低剂量、雌激素灌饲3个月。取第3腰椎包埋切片,检测骨形态计量学参数的改变。结果与去卵巢组,骨灵片各剂量组尤其是中、高剂量组在骨小梁面积百分数、厚度、数量上显著升高,骨小梁分离度、骨形成率、骨矿化沉积率、每毫米破骨细胞数显著下降。结论补肾中药骨灵片具有促进骨形成和抑制骨吸收的作用,使骨结构得到改善。Objective:To observe the histomorphology effects of Gu Ling Pian(GLP)on osteoporosis rats, and explore the therapeutic mechanism of GLP. Methods:36 female 3-month-old SD rats were randomized into six grougs: the shame-operating groug ovariectomized groug(OVX), Gu Ling Pian low、medium、high dosage grougs and ethynylestradiol treated groug .All rats in the later five grougs were ovariectomized, and all rats were given water、Gu Ling Pian、ethynylestradiol respectively 3 months later, double in vivo fluorochrome ...

关 键 词：骨灵片 骨质疏松症 骨形态计量学 中医实验医学 

分 类 号：R285.5[医药卫生—中药学]