吗啡预处理对兔心肌的延迟性保护作用  

Delayed protective effect of morphine preconditioning on rabbit myocardium

作　　者：龙利民[1] 邹定全[2] 谭嵘[2] 

机构地区：[1]中南大学湘雅二医院老年病科,长沙410011 [2]中南大学湘雅二医院麻醉科,长沙410011

出　　处：《中南大学学报（医学版）》2009年第2期135-138,共4页Journal of Central South University ：Medical Science

摘　　要：目的:研究吗啡预处理是否对兔心肌具有延迟性保护作用。方法:将30只健康新西兰大白兔随机分为生理盐水预处理组(NS组)、吗啡预处理12h组(Mor-12组)、吗啡预处理24h组(Mor-24组),每组10只。NS组用生理盐水静脉输注预处理,Mor-12组和Mor-24组用吗啡3mg/kg静脉输注预处理,12h(Mor-12组)或24h(NS组、Mor-24组)后阻断冠状动脉左前降支30min,再灌注120min。其中8只于缺血前(T1)、缺血30min(T2)、再灌注后120min(T3)抽取动脉血测定血清肌钙蛋白I(cardiac troponinI,cTnI)的浓度,并于再灌注毕测定心肌梗死面积,另2只于再灌注毕取心肌行电镜检查,观察心肌细胞超微结构损伤。结果:T2和T3时Mor-24组的cTnI浓度低于NS组和Mor-12组;Mor-24组的心肌梗死面积和心肌细胞超微结构损伤小于NS组和Mor-12组。结论:吗啡预处理对兔心肌具有延迟性保护作用。Objective To investigate whether morphine preconditioning has the delayed protective effect on rabbit myocardium.Methods Thirty New Zealand white rabbits were randomly divided into a NS group,a Mor-12 group and a Mor-24 group(n=10).In the Mor-12 group and Mor-24 group,morphine(3 mg/kg) was infused into rabbits,while the same volume of normal saline(NS) was given to rabbits in the NS group.Twelve hours after morphine infusion in the Mor-12 group,24 h after NS or morphine infusion in the NS group and Mor-24 g...

关 键 词：吗啡 预处理 心肌保护 

分 类 号：R614[医药卫生—麻醉学]