芎麻滴丸对血管性痴呆大鼠学习记忆功能的影响  

Effects of xiongma drop pills on spatial learning and memory ability in rats with vascular dementia

作　　者：赵瑛[1] 滕厚军[1] 祖莹[1] 王巍[1] 李丹[1] 

机构地区：[1]哈尔滨商业大学药学院,150076

出　　处：《实用医学杂志》2009年第5期708-711,共4页The Journal of Practical Medicine

基　　金：黑龙江省科技厅攻关项目(编号:GC03C614-1)

摘　　要：目的:研究芎麻滴丸对血管性痴呆(VD)大鼠学习记忆功能的影响。方法:采用永久性结扎双侧颈总动脉法建立VD大鼠模型,穿梭箱法检测各组大鼠学习记忆能力,HE染色法和尼氏染色法观察大鼠锥体细胞形态和正常神经元计数。结果:与假手术组比较,模型组大鼠学习记忆成绩明显下降,海马CA1区锥体细胞排列稀疏,胞核固缩,正常神经元数量显著减少;与模型组比较,芎麻滴丸中、低剂量组大鼠学习记忆成绩明显提高,海马CA1区锥体细胞损伤减轻,正常神经元数量增加。结论:芎麻滴丸可改善VD大鼠学习记忆障碍,其机制可能与减轻海马CA1区锥体细胞损伤有关。Objective To investigate the effects of xiongma drop pills(XM) on spatial learning and memory ability in rats with vascular dementia(VD).Methods Rat models with VD were constructed by permanent occlusion of bilateral common carotid arteries, and the spatial learning and memory ability of these rats was tested by shuttle box test.Morphological change of pyramidal cells and normal neurons count in CA1 region in hippocampus were observed by HE and Nissl staining.Results As compared with sham group, the learnin...

关 键 词：痴呆 血管性 芎麻滴丸 学习记忆 CA1 

分 类 号：R285.5[医药卫生—中药学]