黑加仑提取物的致突变性和亚急性毒性研究  

Study on Mutagenicity and Sub-acute Toxicity of the Extract from Blackcurrant

作　　者：宋燕华[1] 严峻[1] 夏勇[1] 傅剑云[1] 蔡德雷[1] 郑云燕[1] 

机构地区：[1]浙江省疾病预防控制中心,浙江杭州310051

出　　处：《浙江预防医学》2009年第3期1-3,15,共4页Zhejiang Journal of Preventive Medicine

摘　　要：目的对黑加仑提取物的致突变性和亚急性毒性进行评价,为黑加仑提取物的进一步开发利用提供依据。方法设1.25、2.5和5.0g/kg体重3个剂量观察对小鼠骨髓细胞微核和小鼠精子畸形的影响。设0.625、1.25、2.5g/kg体重3个剂量,观察亚急性毒性。结果各剂量组各项指标均未见有明显的亚急性毒性。各剂量组对小鼠未见有明显的致突变性。结论在本实验条件下,黑加仑提取物无致突变性和亚急性毒性。】Objective To evaluate the mutagenicity and sub-acute toxicity,giving evidence for further exploitation and using of the extract from blackcurrant.Methods 3 different dose groups with 1.25,2.5 and 5.0g/Kg were set for observing the influence on micronucleus of bone marrow cells and sperm abnormalities in mice.A sub-acute toxic study was performed by setting 3 different dose groups with 0.625,1.25,2.5 g/Kg.Results There were no obvious mutagenicity and sub-acute toxicity in all treated groups.Conclusions Und...

关 键 词：黑加仑提取物 亚急性毒性 致突变性 

分 类 号：R114[医药卫生—卫生毒理学]