烧烫酊对家兔深Ⅱ度烧伤后创面愈合作用影响的实验研究  

EXPERIMENTAL STUDY ON EFFECTS OF BURN-SCALD TINCTURE ON HEALING OF RABBITS' SECOND BURN WOUND

作　　者：刘建春[1] 徐爱风[1] 辛存寿[2] 赵果毅[1] 董立[1] 

机构地区：[1]山西中医学院,太原030024 [2]山西中医学院附属医院,太原030024

出　　处：《中国中医药科技》2009年第1期14-16,87,共3页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:研究烧烫酊对家兔深Ⅱ度烧伤后创面愈合的作用。方法:健康家兔60只,随机分为模型组、溶媒组、烧伤灵酊组、烧烫酊治疗Ⅰ组(简称治疗Ⅰ组)、烧烫酊治疗Ⅱ组(简称治疗Ⅱ组)、烧烫酊治疗Ⅲ组(简称治疗Ⅲ组),每组10只。各组家兔造模深Ⅱ度烧伤后,模型组不用任何药物治疗;溶媒组涂抹酒精,烧伤灵酊组涂抹烧伤灵酊;治疗Ⅰ组、Ⅱ组、Ⅲ组分别涂抹不同剂量烧烫酊。观察各组家兔早期创面的大体改变,创面愈合情况,记录结痂时间、原始创面面积,观察皮肤组织病理学变化。结果:治疗各组与模型组、溶媒组在愈合时间上比较有非常显著性差异(P<0.05),治疗Ⅲ组与治疗Ⅰ组、Ⅱ组比较差异显著(P<0.05)。且治疗Ⅲ组瘢痕形成少,愈后效果好。形态学观察明显可见伤后4天、7天、10天,治疗Ⅲ组比模型组、溶媒组毛囊上皮增生、扩展快,且炎症细胞浸润的深度及数量少,伤后16天,治疗Ⅲ组新生表皮已连接成片,表皮层厚,染色深,结构清晰,而模型组、溶媒组新生表皮未完全覆盖创面,新生表皮层厚薄不一。结论:烧烫酊具有促进深Ⅱ度烧伤创面愈合的作用。Objective:To observe the therapeutic effect of burn-scald tincture on deep second burn wound in rabbits.Methods: 60 rabbits were divided into model, solvent, positive and three burn-scald tincture groups,each group was given corresponding drugs respectively after modeling,the gross change at early stage,surface of wound healing,scab time,sureface of wound arca and histopathological changes of skin were observed and recorded.Results: There was obviuos difference between the treated groups and control groups on healing time, the formation rate of scarin in the treated groups was less than that of control. The hair follicle epithelium tissue proliferation in the treated groups was faster than that of control,the number of inflammation cells sinfiltrated was less than that in control on the 4th,7th and 10th day;the fresh epidermis covered wound, which was thicker than normal, the skin structure was clear on the 16th day,the fresh epidermis couldn’t covered the wound in the control groups.Conclusion: Burn-scald tincture can promot the healing of surface of deep second burn wound.

关 键 词：烧伤/中医药疗法 @烧烫酊/治疗应用 外治法 兔 

分 类 号：R285.5[医药卫生—中药学]