丝素-壳聚糖神经导管修复兔面神经缺损的神经电生理变化  

Silk Fibroin-Chitosan Blend as Nerve Conduit for Facial Nerve Regeneration

作　　者：谭学新[1] 马丽[1] 李波[1] 王哲[1] 刘纯义[1] 

机构地区：[1]中国医科大学附属口腔医院颌面外科教研室,口腔解剖生理教研室,沈阳110002

出　　处：《中国医科大学学报》2009年第4期253-255,共3页Journal of China Medical University

基　　金：辽宁省教育厅高校科研基金资助项目(2008843)

摘　　要：目的探讨丝素-壳聚糖混合膜用于面神经缺损修复的可能。方法成年雄性日本大耳白兔20只,切断双侧面神经颊支,制成10mm的兔面神经颊支缺损模型。将丝素-壳聚糖混合膜制作成神经导管,用来修复兔右侧面神经缺损,作为实验组;左侧用翻转自体神经修复,作为对照组。术后2,4,6,8周显微镜下观察面神经修复段的解剖形态,术后4,6,8周行神经电生理检查。结果随时间推移,兔面神经缺损成功再生。结论丝素-壳聚糖神经导管可有效促进兔面神经缺损修复并引导神经再生。神经电生理检查可有效地反映神经缺损修复的功能性变化。Objective To evaluate the feasibility of using silk fibroin-chitosan blend(SFCS)as nerve conduit for facial nerve regeneration.Methods Twenty male adult rabbits were made the models of 10 mm gap on buccal branches of the facial nerve under sterile condition.SFCS nerve conduit was used to repair the right gap of facial nerve,as experimental group.And autologous nerve was grafted into the left gap,as control group.General observation,electrophysilogical study was performed 2,4,6,8 weeks after operation.Result...

关 键 词：面神经缺损 神经再生 神经导管 丝素-壳聚糖混合膜 

分 类 号：R651.3[医药卫生—外科学]