肉豆蔻挥发油对小鼠肝微粒体细胞色素P450的影响  

Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice

作　　者：赵润英[1] 王玮[1] 赵丽妮[1] 李昭[1] 王俊平[1] 

机构地区：[1]沈阳医学院药理学教研室,辽宁沈阳110034

出　　处：《中国中药杂志》2009年第4期447-449,共3页China Journal of Chinese Materia Medica

摘　　要：目的:研究肉豆蔻挥发油对小鼠肝微粒体细胞色素P450的影响。方法:肉豆蔻挥发油按0.4,0.8,1.2mg·g-1剂量每天灌胃2次,连续10d后,用紫外分光光度法检测肝脏微粒体细胞色素P450(CYP)、细胞色素B5(Cytb5)、丙二醛(MDA)和血清谷胱甘肽转移酶(GST)的含量。结果:用药小鼠的肝脏微粒体CYP,Cytb5和血清中GST含量显著增加(P<0.01),并呈现一定的剂量依赖性;而肝脏MDA含量明显降低(P<0.01)。结论:肉豆蔻挥发油对小鼠肝微粒体CYP具有诱导作用。Objective:To study the effect of the volatile oil from nutmeg on liver microsomal cytochrome P450 in mice.Method:Mice were administered the volatile oil from nutmeg at 0.4,0.8 and 1.2 mg·g-1,respectively,twice a day for 10 days.And then,the contents of liver microsomal cytochrome P450(CYP),cytochrome b5(Cytb5),MDA and GST in serum were examined by UV chromatography method.Result:The contents of liver CYP,Cytb5 and GST in serum were increased significantly(P<0.01) and the contents of MDA was reduced signi...

关 键 词：肉豆蔻挥发油 小鼠 肝微粒体细胞色素P450 诱导作用 

分 类 号：R285.58[医药卫生—中药学]