小檗碱微乳的制备及大鼠在体肠吸收  

Study on preparation of berberine microemulsion and its absorption in intestine

作　　者：桂双英[1,2] 吴蕾 潘君 温志强 开伟华[2] 王均[1] 

机构地区：[1]中国科技大学化学与材料科学学院,安徽合肥230027 [2]安徽中医学院药学院安徽省现代中药重点实验室,安徽合肥230031

出　　处：《中国中药杂志》2009年第4期398-401,共4页China Journal of Chinese Materia Medica

基　　金：安徽省优秀青年科技基金计划(06043094)

摘　　要：目的:制备小檗碱微乳,考察其理化性质及大鼠在体肠吸收。方法:利用伪3元相图得到空白微乳的优化处方,制得小檗碱微乳;考察了小檗碱微乳的黏度、电导率、折光率、粒径;运用大鼠在体肠回流模型,采用紫外分光光度法测定回流液中小檗碱含量,分析其肠吸收特性。结果:小檗碱微乳的黏度、电导率、折光率、平均粒径分别为2.11cPa·s,125.5μΩ,1.363,24.0nm。小檗碱在回肠段的吸收速率最快,小檗碱微乳在回肠段的吸收较小檗碱原料药明显增加(P<0.01)。结论:微乳能促进小檗碱在大鼠小肠的吸收。Objective:To prepare berberine microemulsion,and to investigate its properities and the absorption character in rat intestine in situ.Method:The optimum formulation of the blank microemulsion selected by pseudo tertiary phase diagrams and the berberine microemulsion was prepared based on the blank microemulsion.The viscosity,conductance,refraction rate and particle size of berberine microemulsion were surveyed.An in situ rat perfusion method was used to investigate the intestinal absorption of berberine mic...

关 键 词：小檗碱 微乳 肠吸收 

分 类 号：R283[医药卫生—中药学]