附子炮制前后有效部位强心作用的实验研究  

Experimental research on cardiotonic effect of active compoud from raw and processing aconite roots

作　　者：王立岩[1] 张大方[1] 曲晓波[1] 张志仁[1] 王奕琛[1] 

机构地区：[1]长春中医药大学,吉林长春130117

出　　处：《中国中药杂志》2009年第5期596-599,共4页China Journal of Chinese Materia Medica

基　　金：国家重大基础研究项目计划(973)(2006CB504706)

摘　　要：目的:研究附子炮制前后有效部位的强心作用。方法:采取离体蛙心灌流的方法检验附子炮制前后有效部位强心作用,并初步考察有效部位的量效关系;采用股静脉注射戊巴比妥钠对大鼠造成急性心力衰竭,观察附子炮制前后有效部位经十二指肠给药对大鼠血流动力学影响,进一步阐明其强心作用。结果:附子炮制前后有效部位对离体蛙心有增大振幅作用(P<0.05),最大增幅91.11%±87.66%(P<0.01),对振动频率无显著作用;对在体大鼠血流动力学指标左室内压(LVSP),左室最大上升速率+dp/dtm ax,左室最大下降速率-dp/dtm ax,左室舒张末期压(LVEDP)有显著性差异(P<0.01,P<0.001),各给药组心衰大鼠心率变化无显著性差异。结论:附子炮制前后有效部位在离体蟾蜍与在体大鼠上均有强心作用。Objective: To investigate the cardiotonic effect of active compoud from raw and processing aconite roots used rats with acute heart failure(AHF) as the experimental animals.Method: Isolated toad cordis was employed to observe the cardiotonic effect and the AHF models were reproduced in rats by pentobarbital sodium to observe the hemodynamics marker acute heart failure,and elucidate cardiotonic effect.Result: The DDAS and MDA-P improved contractile force obviously on isolated toad cordis(P<0.05).And the m...

关 键 词：附子 有效部位 蟾蜍 大鼠 强心作用 

分 类 号：R285.5[医药卫生—中药学]