荭叶心通软胶囊中川芎超临界流体萃取工艺研究  

Studies on extraction of Ligusticum chuanxiong in Hongye Xintong soft capsule by super critical fluid extraction

作　　者：兰燕宇[1] 郑林[1] 黄勇[1] 王爱民[1] 李勇军[1] 何迅[1] 王永林[1] 

机构地区：[1]贵阳医学院药学院,贵州贵阳550004

出　　处：《中国中药杂志》2009年第2期161-164,共4页China Journal of Chinese Materia Medica

基　　金：国家科技支撑计划课题(2006BAI06A01-03);贵州省中药现代化科技产业项目[黔科合中药专字(2003)12号]

摘　　要：目的:采用超临界流体萃取法,探讨荭叶心通软胶囊中川芎提取工艺的合理性。方法:以藁苯内酯转移率和得油率为指标,用正交试验优化超临界流体萃取川芎的工艺条件。并以川芎超临界流体萃取物和传统蒸馏法提取物分别组成的复方进行大鼠冠脉结扎所致心肌缺血试验比较。结果:超临界流体萃取川芎的最佳工艺条件为萃取压力30 MPa,萃取温度50℃,萃取时间4 h;解析压力10 MPa、解析温度40℃。结论:超临界流体可有效萃取川芎中活性成分。Objective:To study the rationality of extraction prosess for the Ligusticum chuanxiong in Hongye Xintong Soft Capsule by super critical fluid extraction(SFE).Method:Conditions for the extraction were optimized by orthogonal experimental design as guided by the extraction rate and content of lignstilid in the extract;Combined with the experiment of rats ligated the left coronary artery,the two compounds containing different extracts (steam distillation and SFE) were compared to determine the extraction prose...

关 键 词：荭叶心通软胶囊 川芎 超临界流体萃取 工艺研究 药效学评价 

分 类 号：TQ461[化学工程—制药化工]