速效救心丸对大鼠心肌梗死模型血管新生作用的影响  

Influence of effect of Suxiao Jiuxinwan on angiogenesis in experimental myocardial infarction rats

作　　者：冯玲[1] 王阶[1] 陈双厚[1] 刘瑞华[1] 褚福永[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中药杂志》2009年第6期748-750,共3页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(973)项目(2003CB517103);北京市自然科学基金项目(7062058)

摘　　要：目的:研究速效救心丸对实验性心肌梗死大鼠心脏的促血管新生作用。方法:利用SD大鼠冠状动脉结扎法结造成急性心梗(AMI)模型,观察速效救心丸对AMI大鼠心梗面积及梗死边缘区心肌微血管密度的变化。结果:速效救心丸高、低剂量组与模型组梗死面积比较,均有极显著性差异(P<0.01),且有一定的剂量依赖性,与阳性对照组作用相似;速效救心丸高、低剂量组与假手术组相比较,其心肌梗死边缘区的平均血管面密度(MVD)均明显增多(P<0.05),速效救心丸高剂量组与阳性对照组作用相似,但速效救心丸高、低剂量组比较无统计学意义上的差异(P<0.05)。结论:速效救心丸对实验性心肌梗死大鼠的心脏有明显的促血管新生作用。Objective:To study the effect of Suxiao Jiuxinwan on angiogenesis in experimental myocardial infarction rats.Method:The animal model was established by ligation of anterior decending coronary artery and the infarction areas as well as microvascular density(MVD) in the marginal infarction area of the myocardial infarction rats were observed.Result:Infarction areas in high dose and low dose Suxiao Jiuxinwan groups were significantly different from that of model group(P<0.01),and this effect was similar wit...

关 键 词：速效救心丸 大鼠急性心梗模型 血管新生 

分 类 号：R285.5[医药卫生—中药学]