内蒙古绒山羊毛囊不同发育时期BMP2、Noggin及SHH基因在皮肤中的表达  

The expression of BMP2,Noggin,SHH in the skin of Inner Mongolia cashmere goat from different stage of hair follicle development

作　　者：苏蕊[1] 张文广[1] 常子丽[1] 王瑞军[1] 李金泉[1] 

机构地区：[1]内蒙古农业大学动物科学与医学学院,内蒙古呼和浩特010018

出　　处：《扬州大学学报（农业与生命科学版）》2009年第1期54-57,共4页Journal of Yangzhou University：Agricultural and Life Science Edition

基　　金：国家自然科学基金重点资助项目(30660122);内蒙古自治区自然科学基金重大项目(200408020401)

摘　　要：采用功能分类基因芯片方法,分析内蒙古绒山羊皮肤毛囊发育兴盛期和休止期BMP2、Noggin及SHH基因在皮肤中的表达,探讨其对毛囊发育的作用方式。结果表明:与兴盛期相比,休止期BMP2、Noggin及SHH基因表达分别上调24.61倍、下调0.16倍、下调0.22倍。BMP基因可抑制毛囊发育,且与维持毛囊处于休止期有关;在毛囊发育兴盛期,Noggin基因起强抑制BMP2基因表达的作用;在毛囊发育过程中,Noggin对BMP2基因的抑制作用至少是部分通过SHH实现的。The expression of BMP2,Noggin,SHH in the skin of Inner Mongolia cashmere goat from different stage of hair follicle development were explored by GEArray S series stem cell array(Supper Array),to explain the mode of action of these genes during the development and cycling of hair follicle.The results showed that the expression of BMP2 was upregulated in the skin in telogen,whereas it expressed weakly in anagen.It was different from BMP2,Noggin and SHH were up-regulated in the skin in anagen and expressed wea...

关 键 词：山羊 毛囊发育 BMP2基因 Noggin基因 SHH基因 表达 

分 类 号：S827[农业科学—畜牧学]