聚对二氧环己酮/聚乙二醇多嵌段共聚物的合成与表征  

SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC MULTIBLOCK COPOLYMERS BASED ON POLY(p-DIOXANONE) AND POLY(ETHYLENE GLYCOL)

作　　者：牟玉蓉[1] 石静[1] 陈思喆[1] 王玉忠[1] 

机构地区：[1]四川大学化学学院环境友好高分子材料教育部工程研究中心,成都610064

出　　处：《高分子学报》2009年第3期203-208,共6页Acta Polymerica Sinica

基　　金：国家杰出青年科学基金(基金号50525309)资助项目

摘　　要：首先合成双端羟基的聚对二氧环己酮预聚物(PPDO)和双端羧基的聚乙二醇预聚物(PEG),然后以丁二酸酐/二环己基碳二亚胺(DCC)将PPDO与PEG偶联共聚,得到PPDO/PEG多嵌段共聚物.通过1H-NMR和GPC表征了聚合物的结构和分子量.采用差示扫描量热法(DSC)和热重分析(TGA)研究了共聚物的结晶性能和热稳定性.用透析法制备了共聚物纳米粒子,并用动态光散射(DLS)表征了共聚物纳米粒子的粒径及分散度,结果表明,随着共聚物亲水链段PEG含量的增加,其纳米粒子更易形成,粒子粒径随共聚物分子量增大而增大.In order to overcome the defects of poly(p-dioxanone)(PPDO) due to its hydrophobicity,amphiphilic PPDO/poly(ethylene glycol)(PEG) multiblock copolymers were synthesized by coupling the dihydroxyl-terminated PPDO with dicarboxylic acid-terminated PEG.The structures and molecular characteristics of the resulting PPDO/PEG multiblock copolymers were studied by^1H-NMR and GPC.The crystallization and thermal stability of the copolymers were studied using DSC and TGA.DSC analysis showed that the PPDO blocks restra...

关 键 词：聚对二氧环己酮 聚乙二醇 嵌段共聚物 两亲性 纳米粒子 

分 类 号：O633[理学—高分子化学]