视网膜母细胞瘤患者及其父母SCE自发及MMC诱发频率的相关研究  

STUDY ON THE RELATIONSHIP BETWEEN THE SP ONTANEOUS AND MMC-INDUCED SCE OF PATIENTS WITH RB AND THEIR PARENT

作　　者：周宏远[1] 吕煦春[1] 李世绩[1] 高秀坤[1] 罗成仁[2] 李安仁[2] 

机构地区：[1]华西医科大学附一院肿瘤研究所,成都610041 [2]华西医科大学附一院眼科教研室,成都610041

出　　处：《四川大学学报（自然科学版）》2000年第S1期230-233,共4页Journal of Sichuan University(Natural Science Edition)

摘　　要：目的　探讨RB患儿与其父母自发及MMC诱发SCE的相关性 .方法　采用微量全血培养法制备淋巴细胞染色体及姐妹染色单体分化染色 (SCD)法进行SCE分析 .结果RB患儿自发和诱发频率 (10 .81/细胞 ,2 9.35/细胞 )高于小儿对照 (7.50 /细胞 ,2 3.2 6 /细胞 ) ,P<0 .0 1;RB患儿SCE自发频率 (10 .81/细胞 )与其父母 (10 .6 2 /细胞 )无统计学意义 ,P >0 .0 5;RB患儿SCE诱发频率 (2 9.35/细胞 )高于其父母 (2 6 .2 4 /细胞 ) ,P <0 .0 1;RB患儿父母SCE自发诱发频率 (10 .6 2 /细胞 ,2 6 .2 4 /细胞 )均高于成人对照 (8.6 6 /细胞、2 2 .2 5/细胞 ) ,P<0 .0 1.结论　RB患儿SCE自发及诱发频率与其父母自发及诱发频率相关性不明显 ,P >0 .0 5,RB患儿的染色体不稳定性和潜在不稳定性可能由其父母遗传而来 .Objective Exploration of t he relationship between the spontaneous and induced SCE of patients with RB and their parents. Methods the SCE analysis was used by peripheral blood lymphocyted cultrures and sister chromatid difference with sta ning technique. Results the mean spontaneous and MMC induced SCE per cell was 10.81 and 29.35 in RB patients, 8.66 and 22.25 in adults controls, No di fferences was observed in the spontaneous SCE freque...

关 键 词：视网膜母细胞瘤 SCE 染色体不稳定性 

分 类 号：Q324[生物学—遗传学]