高胆固醇血症兔主动脉功能变化的研究  

Effects of Hypercholesterolemia on Vascular Function

作　　者：王景全[1] 张砚[1] 白小涓[1] 徐峰[1] 于雅媛[1] 

机构地区：[1]中国医科大学第一临床学院循环内科,沈阳110001

出　　处：《中国医科大学学报》2000年第S1期42-43,共2页Journal of China Medical University

摘　　要：目的 :探讨高胆固醇血症对血管功能的影响。方法 :应用组织 -器官水浴系统 ( tissue- organ bath system )观察高胆固醇饮食饲养 4周的兔及正常饮食饲养的兔游离主动脉对血管活性物质的反应。结果 :与正常饮食组比较 ,高胆固醇血症组血管对腺苷的舒血管反应明显减弱 ;对去甲肾上腺素缩血管反应明显增强。结论 :高胆固醇血症使腺苷血管舒张反应减弱 ;使去甲肾上腺素缩血管反应性增强。Objective:Our purpose was to determine if hypercholesterolemia has any effects on vascular function. Methods:Twenty New Zealand male rabbits were randomly divided into two groups(10 rabbits each):normal diet (NC) and 0.5%cholesterol diet (HC).Four weeks later,descending aorta was excised from each animal,5mm wide aortic rings were placed vertically between hooks in tissue organ bath system containing 25 ml Krebs solution,then maintained at 37℃ and bubbled with a mixture of 95% O 2 and 5% CO 2.After 60 mi...

关 键 词：高胆固醇血症 血管功能 

分 类 号：R589.2[医药卫生—内分泌]