非胰岛素依赖型糖尿病患者血清PICP、ICTP测定及其与骨代谢的关系  

Serum PICP,ICTP and Bone Metabolism in Type 2 Diabetics

作　　者：陶耕[1,2] 蔡俊峰[1,2] 陈国瑞[1,2] 李永加[1,2] 

机构地区：[1]福建医科大学附属第二医院内科 [2]福建医科大学糖尿病研究室,泉州362000

出　　处：《福建医科大学学报》2000年第S1期25-27,共3页Journal of Fujian Medical University

摘　　要：目的　探讨非胰岛素依赖型糖尿病 (2型糖尿病 )对骨代谢的影响。　方法　对 30例 2型糖尿病患者及 40例正常人 (对照组 )血清 I型前胶原羧基末端前肽 (PICP)、I型胶原羧基吡啶并啉交联肽 (ICTP)、骨钙素(BGP)、钙 (Ca)、磷 (P)等骨代谢相关指标进行测定。　结果　 2型糖尿病患者血清 ICTP较对照组明显增高 (P<0 .0 1) ,PICP/ ICTP则较对照组明显降低 (P<0 .0 1) ,血清 PICP、BGP较对照组降低 ,但差异无显著性 (P>0 .0 5 ) ,血清 Ca、P与对照组无显著性差异。血清 ICTP与病程呈正相关 (r=0 .474,P<0 .0 1) ,血清 PICP与 BGP呈正相关(r=0 .5 89,P<0 .0 1)。　结论　 2型糖尿病患者骨吸收过程增加较为明显 ,造成骨量丢失。Objective To explore the change of bone metabolism in type 2 diabetes mellitus. Methods Serum carboxyterminal propeptide of type I procollagen(PICP),carboxytermina telopeptide of type I collagen(ICTP),bone giaprotein(BGP),Calcium(Ca),Phosphorus(P) were measured in 30 of type 2 diabetic patients and 40 controls.\ Results\ Serum ICTP in type 2 diabetic patients was significantly higher than that of controls(P<0.01),PICP/ICTP in type 2 diabetic patients was significantly lower than that of controls(P<0.0...

关 键 词：糖尿病 非胰岛素依赖型 I型前胶原羧基末端前肽 I型胶原羧基吡啶并啉交联肽 骨钙素 

分 类 号：R587.1[医药卫生—内分泌]