Th_1/Th_2失衡与风寒乘虚犯肺证相关性的研究  

STUDY ON RELATIONSHIP BEIWEEN DISORDER OF SERUM Th_1/Th_2 BALANCE IN RATS WITH SYNDROME OF INVADING LUNGS BY WIND-COLD PATHOGENS AT DEFICIENCY

作　　者：张伟[1] 赵润杨[2] 林丽[2] 王立娟[2] 

机构地区：[1]山东中医药大学附属医院,济南250011 [2]山东中医药大学,济南250014

出　　处：《中国中医药科技》2009年第3期161-162,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：山东省卫生系统高层次人才1020工程资助项目;山东省科技厅科技攻关基金资助项目No.Y2006C113

摘　　要：目的:探讨Th1/Th2失衡在风寒乘虚犯肺证形成中的作用与机理。方法:采用熏烟及气管内加滴脂多糖方法复制风寒乘虚犯肺大鼠模型,ELISA法检测大鼠血清中IL-4、INF-γ水平并计算INF-γ/IL-4比值。结果:风寒乘虚犯肺组大鼠血清IL-4水平高于正常对照组(P<0.05),而IFN-γ水平较正常对照组显著降低(P<0.01),IFN-γ/IL-4比值降低(P<0.05)。结论:Th1/Th2失衡参与气道炎症反应,是风寒乘虚犯肺证形成的重要物质基础。Objective:To discuss the effects of Th1/Th2 unbalance in formation of lung-qi insufficiency and the mechanism.Meothods: Models with invading lungs by wind-cold pathogens at deficiency were made by smoking and endotracheal LPS, serum IL-4 and INF-γ were tested by ELISA.Results: The serum IL-4 level was obviusly higher in rats of invading lungs by wind-cold pathogens at deficiency than that of normal group, the serum INF-γ level was obviusly lower than that of normal, the ratio of INF-γ/IL-4 was lowered significantly.Conclusion: Th1/Th2 unbalance was the important pathogenic basis of formation of invading lungs by wind-cold pathogens at deficiency syndrome.

关 键 词：肺气虚 风寒乘虚犯肺 IL-4/血液 INF-γ/血液 辨证规范化 大鼠 

分 类 号：R256.1[医药卫生—中医内科学]