急性冠状动脉综合征院前急救中应用替罗非班的有效性和安全性研究  

Clinical Efficacy and Safety of Tirofiban in Pre-hospital Emergency Service for Patients with Acute Coronary Syndrome

作　　者：叶泽兵[1] 张刚庆[1] 杨旺明[1] 饶先伟[1] 赵雅红[2] 李克明[2] 

机构地区：[1]广东省第二人民医院急诊科,510317 [2]广东省第二人民医院心内科,510317

出　　处：《岭南急诊医学杂志》2009年第1期15-17,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:研究急性冠状动脉综合征(ACS)患者在院前急救中应用替罗非班的有效性和安全性。方法:将2005年5月至2008年5月连续的78例ACS患者随机分为治疗组和对照组,前者院前急救中给予替罗非班,后者常规治疗,两组入院以后即刻行PCI术,比较两组PCI术后即刻罪犯血管(CV)的TIM I血流分级,术后6、12 h肌酸激酶同工酶(CK-MB)的改变以及术后30 d内的主要不良心脏事件(MACE)的发生率、术后出血的发生率和需要输血的比例。结果:术后即刻治疗组和对照组CV的TIMI血流分级、CK-MB值方面治疗组明显优于对照组,而两组间术后30d的MACE发生率以及术后出血、输血的比例差异无统计学意义。结论:ACS患者院前急救中使用替罗非班是安全、有效的,其疗效优于常规治疗。Objective:To investigate the efficacy and safety of glycoproteinⅡb /Ⅲa inhibitor(tirofiban) for patients with acute coronary syndrome(ACS) in pre-hospital emergency services.Methods:78 ACS patients admitted between May 2005 and May 2008 were randomly divided into the tirofiban group and conventional interventional group.The coronary reperfusion flow(TIM I grades) of culprit vessel(CV) after PCI,cardiac enzyme changed 6 hrs and 12 hrs afterwards,major adverse cardiac events(MACE) rates within 30 days,bleeding and transfusion rates were analyzed and compared between the two groups.Results:The average TIMI reperfusion grades and CK-MB levels at 6 hrs and 12 hrs after PCI were better in the tirofiban group than in the conventional group respectively. There were no differences of MACE rates within 30 days after PCI and of complications of bleeding and transfusion rates between the two groups.Conclusion:The results suggest that tirofiban is a safe and more efficacious therapy for patients with ACS in pre-hospital emergency services.

关 键 词：急性冠状动脉综合征 院前急救 替罗非班 经皮冠状动脉介入治疗 

分 类 号：R541.4[医药卫生—心血管疾病]