舒芬太尼对比氟比洛芬酯联合用药在腔镜甲状腺切除术后静脉自控镇痛的临床研究  

Effect of Sufentanil Used Alone or in Combination with Flurbiprofen Axetil for Postoperative Patient-controlled Intravenous Analgesia in Patients Underwent Endoscopic Thyroidectomy

作　　者：王昊[1] 季中华[1] 乔瑞冬[1] 

机构地区：[1]广东省珠海市人民医院麻醉科,519000

出　　处：《岭南急诊医学杂志》2009年第2期119-120,共2页Lingnan Journal of Emergency Medicine

摘　　要：目的:观察腔镜甲状腺切除术后患者自控静脉镇痛(PCIA)中单纯舒芬太尼对比氟比洛芬酯与舒芬太尼联合用药的镇痛效果与不良反应。方法:选择ASA Ⅰ～Ⅱ级腔镜甲状腺切除术后行PCIA患者60例,随机均分为两组。舒芬组术后PCIA予舒芬太尼100μg和昂丹司琼8 mg加入100 mL生理盐水中;联合组术后PCIA予氟比洛芬酯100 mg、舒芬太尼50μg和昂丹司琼8 mg加入100 mL生理盐水中,手术结束前10 min静脉予氟比洛芬酯50 mg为负荷剂量。两组PCIA泵的设置为维持量2 mL/h,单次负荷剂量0.5 mL,锁定时间15 min。观察两组术后48 h的镇痛评分(VAS)、镇静评分(SS)及不良反应。结果:两组术后镇痛及镇静评分差异无显著意义,联合组药物不良反应发生率低于舒芬组。结论:氟比洛芬酯联合舒芬太尼在腔镜甲状腺切除术后PCIA效果与单纯舒芬太尼相似,但不良反应减少,提高了镇痛质量。Objective: To evaluate the effect and side effect of postoperative patient-controlled intravenous analgesia (PCIA) with the mixture of sufentanil and flurbiprofen axetil or sufentanil used alone in patients underwent endoscopic thyroidectomy. Methods: 60 cases should be ASA class Ⅰ or Ⅱ were randomly divided into two groups equally with 30 cases each. Sufentanil Group was given sufentanil 100 μg plus ondansetron 8mg diluted to 100mL via PCIA after surgery. Mixture Group was administrated sufentanil 50 μg, and flurbiprofen axetil 100 mg plus ondansetron 8 mg diluted 100 raL via PCIA after surgery, the loading dose was flurbiprofen axetil 50 mg ten minutes prior to the end of the operates. The PCIA rate was 2 mL/h, blous 0.5 mL, lock time 15 min. Analgesia and sedation grade were accessed and side effects were recorded. Results: There was no significant difference in analgesia and sedation grade between two groups. The side effects were lower in Mixture Group than those in Sufentanil Group. Conclusion: Co-administration of flurbiprofen axetil with sufentanil by PCIA offers overall favorable analgesic responses as well as the reduction of sufentanil consumption during PCIA in the patients following endoscopic thyroidectomy.

关 键 词：腔镜甲状腺切除术 舒芬太尼 氟比洛芬酯 镇痛 

分 类 号：R614[医药卫生—麻醉学]