川芎嗪酯类衍生物在内皮细胞氧化损伤中的保护作用  

Protective Effects of Tetramethylpyrazine Diester Derivatives on Endothelial Cells Injured by Hydrogen Peroxide

作　　者：崔磊[1] 丁倩[1] 刘新泳[2] 王守训[1] 

机构地区：[1]潍坊医学院生物化学与分子生物学教研室,山东潍坊261042 [2]山东大学药学院

出　　处：《潍坊医学院学报》2009年第2期135-137,Ⅱ,共4页Acta Academiae Medicinae Weifang

摘　　要：目的观察川芎嗪酯类衍生物对H_2O_2引起的体外培养人脐静脉内皮细胞氧化性损伤的保护作用,并初步探讨川芎嗪双酯衍生物在家兔动脉内皮氧化损伤中的保护作用。方法 H_2O_2引起体外培养人脐静脉内皮细胞及家兔动脉内皮氧化性损伤,观察川芎嗪双酯衍生物对内皮细胞氧化损伤的保护作用。结果在各试验浓度,大多数川芎嗪双酯衍生物对H_2O_2引起体外培养人脐静脉内皮细胞氧化性损伤有明显的保护及促增殖作用,A6在较高浓度对家兔动脉内皮的氧化损伤有保护作用。结论川芎嗪酯类衍生物对H_2O_2引起的体外培养人脐静脉内皮细胞氧化性损伤有明显保护作用,其中以A15效价最高,在其作用机制进一步研究中值得注意。Objective To investigate the protection of tetramethylpyrazine diester derivatives(TMPD) on oxidative damage in human umbilical vein endothelial cells(HUVECs),and its protection from oxidative damage on rabbits' arterial endothelium.Methods The HUVECs cells and rabbits' arterial endothelium were damaged by H_2O_2.The protective effect of TMPD on endothelial cells was obseved.Results Most kinds of TMPD have significant protection on the oxidative damaged HUVECs caused by H_2O_2.At a higher concentration A6 has a protective effect on oxidative damage of rabbits'arterial endothelium.Conclusion TMPD have potent protection on oxidative damage,and it is worth paying attention in the further study.

关 键 词：川芎嗪衍生物 内皮细胞 氧化损伤 

分 类 号：R543.5[医药卫生—心血管疾病]