老年冠心病患者超敏C-反应蛋白水平与冠状动脉粥样硬化易损斑块检出情况分析  

Level of High-Sensitive C-reactive Protein and Vulnerable Plaque in Elderly Patients with Coronary Atherosclerosis

作　　者：潘永瑜[1] 刘芳[1] 刘蓓菁[1] 

机构地区：[1]上海交通大学医学院附属新华医院老年科,上海市200090

出　　处：《中国全科医学》2009年第13期1209-1210,共2页Chinese General Practice

摘　　要：目的探讨老年冠心病患者超敏C-反应蛋白(hs-CRP)水平与冠状动脉粥样硬化易损斑块的检出情况。方法选取63例老年冠心病患者,近期有心绞痛发作的不稳定型心绞痛患者32例为Ⅰ组,近2年内无明显心绞痛发作者31例为Ⅱ组,分别进行血清hs-CRP定量检测及冠状动脉CT血管造影(CTA)检查,比较两组的血清hs-CRP水平和易损斑块的检出率。结果Ⅰ组有易损斑块者27例(84.38%),Ⅱ组有易损斑块者9例(29.03%),差异有统计学意义(P<0.01)。Ⅰ组血清hs-CRP水平为(5.38±2.96)mg/L,Ⅱ组血清hs-CRP水平为(3.55±2.81)mg/L,差异有统计学意义(P<0.05)。结论近期有心绞痛发作的老年冠心病患者的血清hs-CRP水平较高,易损斑块检出率也较高,炎症反应可能在易损斑块的发生、演变、破裂过程中起着重要的作用。Objective To investigate the level of high-sensitivity C-reactive protein(hsCRP)and detective rate of vulnerable plaque in elderly patients with coronary heart disease.Methods All 65 senile patients with coronary heart disease,including 32 patients with recent angina attack history(group I)and 31 without the history(group II),were enrolled.They were given examination of serum hs-CRP and CT angiography,in order to compare the levels of hsCRP and detective rates of vulnerable plaque between the two groups.Results The detective rate of vulnerable plaque in group I was 84.38%(27/32),being significantly higher than 29.03%(9/31)in the group II(P<0.01),and the level of hsCRP in group I was(5.38±2.96)mg/L,being significantly higher than(3.55±2.81)mg/L in the group II(P<0.05).Conclusion The level of serum hs-CRP of the senile patients with coronary heart disease complicated by recent angina attack is higher,and the detective rate of atherosclerotic vulnerable plaque is also higher.It is suggested that inflammatory reaction could play an important role in development,progression and rupture of coronary vulnerable plaque.

关 键 词：冠状动脉疾病 易损斑块 C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]