碱性成纤维细胞生长因子-2在Graves眼病发病机制中的作用  

The Role of Basic Fibroblast Growth Factor-2 in Pathogenesis of Graves′ Ophthalmopathy

作　　者：叶小珍[1] 王坚[1] 胡兰萍[1] 顾萍[1] 李洁[1] 邵加庆[1] 王燕燕[1] 

机构地区：[1]南京军区总医院内分泌科,江苏省南京市210002

出　　处：《中国全科医学》2009年第16期1530-1531,共2页Chinese General Practice

基　　金：江苏省自然科学基金资助项目(BK2007574);南京军区南京总医院青年基金资助项目(Q2008010)

摘　　要：目的探讨碱性成纤维细胞生长因子-2(bFGF-2)在Graves眼病(GO)发病机制中的作用。方法选择20例GO患者(研究组)和20例单纯甲状腺功能亢进而无眼征的患者(对照组),检测两组患者血清bFGF-2及透明质酸(HA)水平,并将两组检测结果进行比较,分析与bFGF-2水平相关的因素。结果研究组患者bFGF-2、HA水平分别为(98±28)pg/ml和(551±316)ng/ml,对照组分别为(77±20)pg/ml和(351±249)ng/ml,两组患者bFGF-2、HA水平比较差异均有统计学意义(t值分别为2.73和2.22,P<0.05)。将bFGF-2水平与患者的年龄、病程、HA水平及GO活动度评分(CAS)进行相关性分析,发现bFGF-2水平与HA水平及CAS呈正相关(r值分别为0.57和0.35,P<0.05)。结论GO患者外周血bFGF-2水平明显升高,提示bFGF-2可能在GO的发病机制中起重要作用,同时bFGF-2亦是判断GO活动性的指标。Objective To investigate the role of basic fibroblast growth factor-2(bFGF-2)in the pathogenesis of Graves′ophthalmopathy (GO).Methods Twenty GO patients(research group) and 20 with simple hyperthyroidism without eye symptoms(control group) were enrolled to determine serum bFGF-2 and hyaluronic acid(HA) levels.The results were compared to find out the factors related to bFGF-2.Results The mean HA level was significantly higher in research group(551±316 ng/ml) than in control(351±249 ng/ml) (P<0.05);the bFGF-2 level increased significantly in research group(98±28 pg/ml) as compared with control (77±20 pg/ml) (P<0.05).Spearman regression analysis showed that HA level and clinical activity score(CAS) were significantly correlated with bFGF-2 level(P<0.05).Conclusion The bFGF-2 level in peripheral blood increases significantly,suggesting that bFGF-2,an indicator determining GO activity,may play an important role in GO pathogenesis.

关 键 词：GRAVES眼病 成纤维细胞生长因子 碱性 透明质酸 

分 类 号：R581[医药卫生—内分泌]