健康男性汉族青年进入高原地区后血常规变化与复方新诺明药动学之间的关系  

Effects of the Blood Components Changes on the Pharmacokinetics of SMZ CO after the Healthy Young Males Entered the High Altitude

作　　者：高芬[1] 华毛[1] 

机构地区：[1]青海大学附属医院呼吸科,西宁810001

出　　处：《中国医科大学学报》2009年第5期330-332,共3页Journal of China Medical University

基　　金：国家自然科学基金资助项目(30460149)

摘　　要：目的探讨急进与久居高原志愿者血常规变化对复方新诺明药动学影响。方法采用高效液相色谱法测定平原、急进高原和久居高原3组2个群体健康男性汉族青年口服单剂量复方新诺明前后15个时间点血浆药物浓度。应用全自动血细胞分析仪测定3组血常规。结果药动学参数:急进组消除速率常数(Ke)、时间曲线下面积(AUC)、平均驻留时间(MRT)、半衰期(t1/2)、消除率(CLz/F)与平原组有显著性差异,久居组Ke、MRT、t1/2与平原组有显著性差异,急进组t1/2、表观分布体积(V2/F)与久居高原组有显著性差异(P均﹤0.01)。血常规:与平原组比较,急进组和久居组的平均红细胞体积(MCV)、血小板平均容积(MPV)降低,血小板(PLT)、白细胞计数(WBC)和淋巴细胞绝对值(LYMF)增高;急进组血红蛋白(HGB)和红细胞比容(HCT)降低,久居组HGB和WBC高于平原组和急进组(P分别﹤0.05和0.01)。相关性分析:LYMF和PLT与Ke负相关,与MRT和t1/2正相关;MCV与MRT和t1/2负相关(P均﹤0.01,0.05)。结论健康男性汉族青年进入高原地区后血常规变化对复方新诺明药动学有影响。Objective To investigate the effects of blood components changes on the pharmacokinetics of sulfamethoxazole compound(SMZ CO)after the healthy young males entered high altitude. Methods The young volunteers of healthy male Han people were divided into three groups according to the duration they entered high altitude:the plain group,the rapid ascent group and the adaptation group. All sub- jects in this study were treated with a single dose of SMZ CO tablet. Their plasma concentrations of SMZ CO were detecte...

关 键 词：高原 药物代谢动力学 复方新诺明 血常规 

分 类 号：R969.1[医药卫生—药理学]