CA125、CA19-9联合检测在卵巢上皮癌和子宫内膜异位症中的临床价值  

Clinical Value of Serum CA125 and CA19-9 Detection for the Diagnosis of Epithelial Ovarian Cancer and Endometriosis

作　　者：范春明[1] 罗希[2] 温放[2] 

机构地区：[1]中国医科大学附属第四医院人事科,沈阳110032 [2]中国医科大学附属第一医院妇科,沈阳110001

出　　处：《中国医科大学学报》2009年第5期376-378,共3页Journal of China Medical University

基　　金：辽宁省教育厅高校科研基金资助项目(2008812)

摘　　要：目的探讨血清中CA125和CA19-9联合检测在卵巢上皮癌和子宫内膜异位症中的临床价值。方法对2003年9月至2008年9月中国医科大学附属第一医院及第四医院妇科收治的52例卵巢上皮癌、68例子宫内膜异位症及33例卵巢良性肿瘤(对照组)患者的血清CA125和CA19-9水平进行回顾性统计分析。结果卵巢上皮癌组患者血清CA125和CA19-9水平明显高于子宫内膜异位症组和对照组(P<0.05;P<0.01);子宫内膜异位症组患者血清CA125和CA19-9水平明显高于对照组(P<0.05);血清CA125与CA19-9联合测定较单项检测敏感度高且更有临床意义;70U/ml﹤CA125≤140U/ml组,子宫内膜异位症阳性率明显高于卵巢上皮癌(P<0.05),CA125﹥140U/ml组,卵巢上皮癌阳性率明显高于子宫内膜异位症(P<0.01)。结论血清CA125和CA19-9联合测定可提高卵巢上皮癌和子宫内膜异位症的敏感性。CA125以140U/ml作为临界值更有助于区分卵巢上皮癌与子宫内膜异位症。Objective To explore the expression of CA125 and CA19-9 in epithelial ovarian cancer and endometriosis and discuss its clini- cal significance. Methods The expression of CA125 and CA19-9 of 153 patients who admitted to the first affiliated hospital and the fourth affiliated hospital of China medical university from september 2003 to September 2008 were retrospectively reviewed. Results Serum CA125 and CA19-9 levels in epithelial ovarian cancer significantly increased in endometriosis and benign ovarian tumo...

关 键 词：卵巢上皮癌 子宫内膜异位症 CA125 CA19-9 肿瘤标志物 

分 类 号：R711.71[医药卫生—妇产科学]