Alteration of Glucocorticoid Receptor Following Forebrain Ischemia in Gerbil  

作　　者：Yang Chunmei(杨春梅) Li Linxian(李麟仙) 1 Wang Zican(王子灿) 1 Huang Jun(黄 峻) Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China \+1Department of Pathophysiology, Kunming Medical 

出　　处：《Journal of Nanjing Medical University》2000年第1期16-18,共3页南京医科大学学报（英文版）

摘　　要：Objective\ Exploring the alteration of glucocorticoid receptor (GCR) following forebrain ischemia in gerbils. Methods\ Establish a brain ischemia model by occluding bilateral common carotid. The GCR concentrations in forebrain tissue cytosol were detected by radioligand binding assay. The plasma concentrations of cortisol were determined by the method of competitive protein binding analysis. Results\ GCR concentrations had no significant change after 10 min ischemia (P>0 05), while decreased significantly in 1 h ischemia (P<0.01), and reduced more severely in 1 h ischemia followed by 3 h reperfusion (P<0.01). Plasma cortisol increased markedly in 10 min ischemia and 1 h ischemia (P<0.001), while decreased in 1 h ischemia followed by 3 h reperfusion. Conclusion\ GCR concentrations in brain decreased following forebrain ischemia in gerbil.Objective\ Exploring the alteration of glucocorticoid receptor (GCR) following forebrain ischemia in gerbils. Methods\ Establish a brain ischemia model by occluding bilateral common carotid. The GCR concentrations in forebrain tissue cytosol were detected by radioligand binding assay. The plasma concentrations of cortisol were determined by the method of competitive protein binding analysis. Results\ GCR concentrations had no significant change after 10 min ischemia (P>0 05), while decreased significantly in 1 h ischemia (P<0.01), and reduced more severely in 1 h ischemia followed by 3 h reperfusion (P<0.01). Plasma cortisol increased markedly in 10 min ischemia and 1 h ischemia (P<0.001), while decreased in 1 h ischemia followed by 3 h reperfusion. Conclusion\ GCR concentrations in brain decreased following forebrain ischemia in gerbil.

关 键 词：cerebral ischemia receptors  glucocorticoid CORTISOL GERBILLINAE 

分 类 号：R338[医药卫生—人体生理学]