GAP-43 Expression and Pathological Changes of Temporal Infarction in R.ats and Effects of Batroxobin  

作　　者：吴卫平 管兴志 匡培根 张小澍 

机构地区：[1]Neurotransmitter Research Laboratory,Department of Neurology,Chinese PLA General Hospital,Postgraduate Military Medical School,Beijing 100853 [2]Department of Neurology,PLA 261 Hospital,Beijing,100094

出　　处：《Journal of Traditional Chinese Medicine》2002年第1期42-46,共5页中医杂志（英文版）

摘　　要：To study the changes of the expression of growth-associated protein-43 (GAP-43) and pathology in temporal infarction of rats photochemically induced and the effects of batroxobin. METHODS: Immunohistochemical technique and hematoxylin-eosin stain was used to show the changes of the expression of GAP-43 and pathology. RESULTS: In infarction group, GAP-43 expression was markedly increased on the infarction and surrounding tissues at 24 h cerebral infarction. The expression reached peak level at 72 h after cerebral infarction and was decreased at 7 d after cerebral infarction. However, in batroxobin-treated group, GAP-43 expression was increased and the pathological changes were much slight as compared with infarction group. CONCLUSION: The expression of GAP-43 increases in infarction of temporal neocortex and batroxobin promotes the expression of GAP-43 and ameliorates the pathological changes in infarction of temporal neocortex.To study the changes of the expression of growth-associated protein-43 (GAP-43) and pathology in temporal infarction of rats photochemically induced and the effects of batroxobin. Methods: immunohistochemical technique and hematoxylin-eosin stain was used to show the changes of the expression of GAP-43 and pathology. Results: In infarction group, GAP-43 expression was markedly increased on the infarction and surronding tissues at 24h cerebral infarction. The expression reached peak level at 72h after cerebral infarction and was decreased at 7d after cerebral infarction. However, in batroxobin-treated group, GAP-43 expression was increased and the pathological changes were much slight as compared with infarction group. Conclusion: The expression of GAP-43 increases in infarction of temporal neocortex and batroxobin promotes the expression of GAP-43 and ameliorates the pathological changes in infarction of temporal neocortex.

关 键 词：Animals BATROXOBIN Brain Infarction Fibrinolytic Agents GAP-43 Protein Male NEOCORTEX Random Allocation RATS Rats  Wistar Temporal Lobe 

分 类 号：R277.7[医药卫生—中医学]