A Clinical and Experimental Study on the Protective Effects of Jiangzhi Tongmai Fang on Endothelial Injury  

作　　者：王亚红 牛福玲 赵明镜 钟蓓 郝锦红 阎卫红 吕晞滢 王伟 李樯 林谦 戴雁彦 赵勇 肖岷 唐玲 何兰英 蒋学英 郭维琴 王硕仁 鲁伟星 毛树章 

机构地区：[1]Dongzhimen Hospital,Beijing TCM University,Beijing 100700 [2]Beijing Architectural Engineering Hospital [3]Teaching and Research Section of Febrile Diseases,Gansu College of Traditional Chinese Medicine

出　　处：《Journal of Traditional Chinese Medicine》2002年第2期87-92,共6页中医杂志（英文版）

摘　　要：31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang ([symbol: see text], formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, the JZTMF formula showed an effect of regulating blood lipids, and therefore it was antiatherosclerotic. The mechanism is, probably, restoration of the function of endothelial cells (EC) by increasing the synthesis of 6-keto-PGF1 alpha and decreasing the release of endothelin (ET) as evidenced in the experimental study.31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang (降脂通脉方, formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, the JZTMF formula showed an effect of regulating blood lipids, and therefore it was anti-atherosclerotic. The mechanism is, probably, restoration of the function of endothelial cells (EC) by increasing the synthesis of 6-keto-PGF1( and decreasing the release of endothelin (ET) as evidenced in the experimental study.

关 键 词：PHYTOTHERAPY 6-Ketoprostaglandin F1 alpha Animals ARTERIOSCLEROSIS Comparative Study Drug Combinations Drugs  Chinese Herbal ENDOTHELINS Endothelium  Vascular Female Humans Lipoproteins  LDL Cholesterol LOVASTATIN Male Middle Aged Rabbits 

分 类 号：R285.5[医药卫生—中药学]