Studies on the DNA binding and cleavage activity of a synthesized polyamide containing dipeptide Ser-His  

作　　者：ZHANG Zhen NIU MingYu JU Yong ZHAO YuFen 

机构地区：[1]Key Laboratory of Bioorganic Phosphorous Chemistry&Chemical Biology Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084,China

出　　处：《Science China Chemistry》2007年第6期806-811,共6页中国科学(化学英文版)

基　　金：Supported by the National Natural Science Foundation of China(Grant No.20572061)

摘　　要：The DNA binding and cleavage activity of a synthetic polyamide containing dipeptide Ser-His has been investigated by spectroscopic techniques,such as electronic absorbance and circular dichroism(CD)spectropolarimetry,as well as gel electrophoresis.The results show that the molecule has a strong interaction with DNA and can improve DNA-cleavage ability about 100 fold as compared with single dipeptide Ser-His.

关 键 词：POLYAMIDE DNA binding affinity spectroscopy DNA cleavage 

分 类 号：N[自然科学总论]