沙棘果油和籽油抗炎作用的实验研究  

Experimental Study on the Anti-inflammatory Effects of Seabuckthorn Pulp Oil and Seabuckthorn Seed Oil

作　　者：王秉文[1] 林晓茵[2] 王红英[1] 宋杰[1] 王放[3] 王军宪[1] Heikki kallio Yang Baoru 

机构地区：[1]西安交通大学医学院药学系 [2]广东省阳江市卫生学校药理教研室 [3]广东省中山市食品药品监督管理局 [4]Department of Biochemistry and Food Chemistry,University of Turku,FIN-20014 Turku,Finland

出　　处：《沙棘》2007年第3期22-24,共3页Hippophae

摘　　要：为了解研究沙棘果油及沙棘籽油的抗炎作用。用小白鼠耳二甲苯致炎法进行实验,结果表明,与阴性对照组比较,沙棘果油及沙棘籽油高、低剂量组小白鼠耳廓肿胀度明显的减小(P<0.01或P<0.05);沙棘果油及沙棘籽油高、低剂量组间比较,其耳廓肿胀度无明显差异(P>0.05)。结果提示,沙棘果油及沙棘籽油有明显的抗炎作用,并且沙棘果油及沙棘籽油的抗炎作用没有明显差异。用大鼠足跖蛋清致肿法进行实验,结果表明:与阴性对照组比较,沙棘果油及沙棘籽油高、低剂量组大鼠致炎后右后足跖肿胀率无明显变化(均为P>0.05)。鸡蛋清所致大鼠足跖水肿主要以组织胺,5-HT为介质,可能沙棘果油及沙棘籽油对这种炎症模型无明显影响。The experiments aimed at studying the anti-inflammatory effects of seabuckthorn pulp oil(SBPO)and seabuckthorn seed oil(SBSO).The results of the experiment on the method of inducing inflammation in the mouse's ear with dimethylbenzene showed that compared with that of negative control group,the auricular swelling siginificantly lessened in mice of both SBPO high-and low-dose groups and SBSO high-and low-dose groups(P<0.01 or P<0.05).No significant difference was found in auricular swelling degrees between SBPO and SBSO high-dose groups and between SBPO and SBSO low-dose groups(P>0.05).The results suggest that SBPO and SBSO have remarkable anti-inflammatory effects and that the effects do not differ significantly between them.The results of the experiment on the method of inducing metatarsal swelling in rats with egg white showed that compared with that of negative control group,no significant change was found in metatarsal swellings in the right feet after inflammation between SBPO and SBSO high-dose groups and between SBPO and SBSO low-dose groups(P>0.05).Since histamine and 5-hydroxytryptamine are the main transmitters of the rat's metatarsal swelling caused by egg white,SBPO and SBSO have no siginificant effects on this kind of inflammatory model.

关 键 词：沙棘果油 沙棘籽油 抗炎作用 小白鼠 大白鼠 

分 类 号：S793.6[农业科学—林木遗传育种]