特米沙坦治疗高血压病及对血管内皮功能影响的研究  

Estimation of therapeutic effectiveness of temisartan on hypertension and vascuar endothelial function

作　　者：何月光[1] 张富娥[2] 罗炳辉[3] 何世利 迟伟[2] 

机构地区：[1]湖南永州职业技术学院医学院,425006 [2]永州市人民医院心血管内科 [3]永州市第三人民医院 [4]湖南省道县人民医院心血管内科

出　　处：《中国实用医药》2007年第10期41-43,共3页China Practical Medicine

摘　　要：目的观察特米沙坦对高血压病(EH)病人的疗效及内皮血管活性物质内皮素1(ET-1)、一氧化氮(NO)、降钙素基因相关肽(CGRP)和血管紧张素Ⅱ(AngⅡ)的影响。方法对96例EH病人用特米沙坦治疗8周,观察用药前后血ET、NO、CGRP和AngⅡ的变化。结果特米沙坦治疗EH总有效率为91·7%。特米沙坦治疗后血NO、CGRP浓度均较治疗前显著升高(P<0·01),血ET浓度显著下降(P<0·01),AngⅡ水平也升高(P<0·01)。结论特米沙坦有较好的降压作用,可明显改善EH病人血管内皮功能。Objective To evaluate the effects of temisartan on essential hypertension (EH)and endothelial vaso-active substances,such as endothlin-1(ET-1),nitric oxide(NO), calciteonin gene-related peptide(CGRF)and angiotcnsin Ⅱ(AngⅡ)in blood.Methods Ninety-six cases of EH patients were treated with temisartan for 8 weeks.the changes in ET,NO,CGRFandAngIIin blood were observed.Results A total of 91.7% of EH cases were treated cffectively.the concentrations of NO, CGRF and AngII in blood significantrly increased after tretament (P<0.01), but the concentration of ET in blood significanty decreased (P<0.01).Conclusion Temisartan has good action in dccreasing blood pressure,it can significantly improve vascular endothelial function of EH patients.

关 键 词：特米沙坦 高血压病 内皮素1(ET-1) 一氧化氮(NO) 降钙基因相关肽(CGRP) 血管紧张素Ⅱ(AngⅡ) 

分 类 号：R544.1[医药卫生—心血管疾病]