新生乙型肝炎疫苗接种者无应答调查分析  

The investigation of hepatitis B vaccination in non-responders of freshmen

作　　者：邓文强[1] 曾烈华[2] 傅广华[1] 

机构地区：[1]广东省韶关学院医学院免疫病原学教研室,512005 [2]韶关市第一人民医院检验科

出　　处：《中国实用医药》2007年第31期60-62,共3页China Practical Medicine

摘　　要：目的通过新生入学体检测HBsAg和HBs-Ab,了解学生携带乙型肝炎病毒的状态和乙型肝炎疫苗接种者无应答情况。方法用酶联免疫吸附试验(ELISA)测定入学新生人群的HBsAg和HBs-Ab。结果体检总人数为1178人,其中HBsAg阳性170人,占14.43%,HBs-Ab阴性人数为246,占20.88%,经调查接种后抗体阴性者仍然有144人,占16.04%。结论通过调查了解新生中HBsAg携带者和接种乙肝疫苗后无应答者,有助于学生和学校采取必要的措施,尽可能减少乙型肝炎病毒在校园内传播,对乙型肝炎疫苗接种无应答者提出合理的建议,让学生了解自己的免疫状态,以便采取进一步的补救措施。Objective To investigate and analyze the hepatitis B virus carriers and non-responders after hepatitis B vaccination through health examination of HBsAg and HBs-Ab in freshmen.Methods HBsAg and HBs-Ab were determined by enzyme linked immunosorbent assay(ELISA)in 1 178 freshmen.Results The cases of HBsAg positive were 170(the positivity rate was 14.43%)and the number of HBsAb negative were 246(20.88%)in 1 178 freshmen.In freshmen,144(16.04%)kept negative after inoculation of hepatitis B vaccine.Conclusion The investigation showed the HBsAg carriers and non-immune responders after hepatitis B vaccination in freshmen.It helps students and schools to take essential measures to decrease the transmission of hepatitis B virus in campus,and to provide reasonable suggestions and to take compensable measures to non-responder of hepatitis B vaccination.

关 键 词：乙型肝炎疫苗 乙肝病毒表面抗原 乙肝病毒表面抗体 无免疫应答 

分 类 号：R186[医药卫生—流行病学]