短期胰岛素强化治疗对初诊2型糖尿病高血糖毒性作用的影响  

Effect of short-term intensive insulin treatment on hyperglyadmic toxicity in newly diagnosed type Ⅱ diabetic patients

作　　者：杜其玲 郭民容 李传贵[1] 徐晓英[1] 唐红英[1] 

机构地区：[1]四川省威远县人民医院,642450

出　　处：《中国实用医药》2007年第33期15-16,共2页China Practical Medicine

摘　　要：目的探讨胰岛素强化治疗对初诊Ⅱ型糖尿病胰岛-β细胞功能的影响。方法对58例Ⅱ型糖尿病行3个月胰岛素强化治疗,治疗前后行糖负荷实验,检测空腹及餐后2h血糖、胰岛素、C-肽水平。结果初诊Ⅱ型糖尿病行胰岛素强化治疗后血糖、胰岛素、C-肽水平在60min、120min、180min差异有统计学意义(P<0.05),而经保守治疗5年以上药物继发失效,再行强化治疗者则无此差异。结论初诊Ⅱ型糖尿病行胰岛素强化治疗后可减少高血糖毒性作用,改善胰岛-β细胞功能,使部分胰岛-β细胞得到修复。而保守治疗时间长,胰岛素分泌差者,胰岛-β细胞呈不可逆性衰竭。Objective Discuss the effects of intensive insulin therapy on β-cell function in newly diagnosed type Ⅱ diabets patients. Method Freat 58 type Ⅱ diabetic patients for three-month intensive insula therapy(The glucose challege test should be taken during pre-and post-therapy),and then measure the changes of the fasting and 2 hours' post-meal blood sugar,insulin and c-peptide level .Result Great changes(P<0.05)happens in blood sugar ,insulin and c-peptide level at 60 min,120 min and 180 min in newly diagnosed type Ⅱ diabetes patients,but the medical secondary ineffecienly is found after five years' conservative treatment.There are no differences in blood sugar , insulin and c-peptide level affer intensive insulin therapy . Conclusion After intensive insulin therepy the toxic and effects of high blood sugar can be found reduced , and inlet β-cell function is improved and parts of inlet β-cells get repaired ,while it takes a long time to treat the patients by conservative therapy ,especially those who are poor in releasing insulin assumes inversible failure in inlet β-cells .

关 键 词：胰岛素强化治疗 初诊Ⅱ型糖尿病 胰岛-β细胞功能 

分 类 号：R587.1[医药卫生—内分泌]