丹红注射液对2型糖尿病肾病患者CRP、TNF-α水平的影响  

Effect of Danhong injection on CRP、TNF-α in the patients with type-2 diabetic nephropathy

作　　者：张建德[1] 邓建华[1] 伍宗明[1] 左林[1] 王国松[1] 汤文龙[1] 

机构地区：[1]广西省桂林市中医医院内分泌科,541002

出　　处：《中国实用医药》2007年第35期68-70,共3页China Practical Medicine

摘　　要：目的观察丹红注射液对2型糖尿病肾病患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)的影响,探讨丹红注射液治疗2型糖尿病肾病的可能机制。方法采用常规西药加丹红注射液治疗30例2型糖尿病肾病患者为治疗组,取常规西药组30例作为对照组观察,于治疗前后检测患者血液中炎性因子CRP、TNF-α水平。结果丹红注射液治疗2型糖尿病肾病总有效率66.7%,而对照组总有效率为43.3%,两组比较差异有统计学意义(P<0.05);治疗前治疗组CRP、TNF-α水平与对照组比较差异无统计学意义(P>0.05);治疗后治疗组CRP、TNF-α显著降低,与对照组比较差异有统计学意义(P<0.05);治疗组治疗前和治疗后24h尿蛋白量下降与CRP、TNF-α水平呈正相关。结论丹红注射液结合西医治疗对2型糖尿病肾病有效,可能与丹红注射液能调节炎性因子的产生,抑制炎性反应有关。Objective To observe the effect of Danhong injection on CRP、TNF-α in the patients with type-2 diabetic nephropathy and to study the curing mechanism of Danhong injection to diabetic nephropathy.Methods The 30 patients with type-2 diabetic nephropathy were treated with Danhong injection and routine drugs were treatment group.The other 30 diabetic nephropathy patients remedied routinely were the contrast group. The levels of CRP、TNF-α in the blood of patients were tested both before the treatment and after the cure courses.Results The total utility rate(66.7%) of Danhong injection to diabetic nephropathy was significantly higher than that of contrast group(43.3%). After the treatment the levels of CRP、TNF-α in the group treated with Danhong injection were lower than the control group. The decreasing of 24 h urine protein in Danhong injection group were lower and were positively correlated to CRP、TNF-α.Conclusion Danhong injection have significant treatment effect on the patients with type-2 diabetic nephropathy. The curing mechanism of Danhong injection to diabetic nephropathy may be the traditional Chinese medicine can regulate the production of inflammatory factors and can inhibit inflammatory reaction.

关 键 词：丹红注射液 C反应蛋白 肿瘤坏死因子-Α 2型糖尿病肾病 

分 类 号：R259[医药卫生—中西医结合]