胰岛素泵治疗糖尿病的临床疗效观察  

Clinical observation on treatment of diabetes with insulin pump

作　　者：张斌华[1] 华强[1] 夏礼斌 

机构地区：[1]安徽省芜湖皖南医学院弋矶山医院内分泌科,241001

出　　处：《中国现代药物应用》2007年第8期3-5,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨胰岛素泵在糖尿病患者治疗中的治疗效果,并与常规治疗方法进行比较。方法将98例糖尿病患者随机分为两组,分别采用胰岛素泵(即持续皮下胰岛素输注法,CSⅡ)持续皮下注射门冬胰岛素和每天3次皮下注射双相门冬胰岛素治疗,比较两种治疗方法前后血糖,理想降糖所需时间,胰岛素类似物用量,以及低血糖的发生率。结果两组治疗后胰岛素各阶段血糖均较治疗前显著下降(P<0.01),且治疗后泵治疗组平均血糖低于3次皮下注射治疗组,但差异无统计学意义(P>0.05);胰岛素泵治疗组血糖控制达标时间短于3次皮下注射治疗组(P<0.01),胰岛素类似物用量小于3次皮下注射治疗组(P<0.01),且低血糖发生率也明显减少(P<0.05)。结论短期应用胰岛素泵强化治疗可在短时间内使血糖获得理想控制;在血糖控制达标时间及胰岛素类似物用量方面优于3次皮下注射胰岛素类似物,且可有效减少低血糖发生率。Objective AIM to study the efficacy of treatment with insulin pump and conventional insu- lin infusion in patients with diabetes.Methods 8 patients with diabetes were divided into two groups:46 pa- tients were treated with insulin pump continuous subcutaneous insulin infusion(CSⅡ),52 patients accepted con- ventional insulin treatment(CIT)-subcutaneous insulin Aspart infusion 3 times a day.Blood glucose levels before and after treatment,duration to reach the objective glucose level,dosage of insulin analogue and occurrence of hypoglycemia were observed.Results Blood glucose levels decreased significantly after treatment in both groups(P<0.01).The average blood glucose levels after treatment in CSⅡgroup were found lower than those of CIT group,but no significant difference were found(P>0.05).The duration to reach the objective glucose level in CSⅡgroup were found shorter than those of CIT group,dosage of insulin analogue and frequency of hy- poglycemia reaction were found lower than those of CIT group(P<0.01,P<0.01,and P<0.05 respectively). Conclusion Continuous subcutaneous insulin infusion with insulin pump can control hyperglycemia more quickly and effectively and may reduce the dosage of insulin analogue and hypoglycemia risk.

关 键 词：糖尿病 胰岛素泵 胰岛素类似物 持续皮下胰岛素输注 

分 类 号：R587.1[医药卫生—内分泌]