异黄酮化合物的“一锅法”合成工艺  

"One Pot" Synthesis of Isoflavone

作　　者：李洁[1] 

机构地区：[1]南京军区疾病预防控制中心南京军区军事医学研究所,江苏南京210002

出　　处：《江苏化工》2007年第2期38-39,共2页Jiangsu Chemical Industry

基　　金：国家自然科学基金资助(No30450003);江苏省自然科学基金资助(BK2004010)

摘　　要：探索不同催化体系下“一锅法”化学合成异黄酮化合物的工艺。以多元酚和取代苯乙酸衍生物为主要原料,不需分离中间产物,“一锅法”合成得到异黄酮终产物。3种催化体系下均可“一锅法”合成异黄酮化合物,产物结构经理化常数和1HNMR谱确证。以三氟化硼乙醚/三氯化磷为催化剂的“一锅法”合成工艺条件温和,收率较高。This short paper studies the one pot synthesis procedure of isoflavone under three kinds of series,and polyhydric phenols and substituted phenylacetic acid derivatives were used as the major reactants to obtain the target isoflavone compounds. The structure of target isoflavone compound has been confirmed by physical constant and 1HNMR spectrum, and it is conclusive that'one pot'synthesis procedure of isoflavone under BF3·Et2O/DMF/PCl5 series is mild and efficient with high yield.

关 键 词：异黄酮 一锅法 合成 

分 类 号：TQ253.1[化学工程—有机化工]