肾素-血管紧张素-醛固酮系统在慢性心力衰竭中的意义  

The changes and signi ficance of renin-angiotensin-aldostcronelactivity in patients with chronic heart failure

作　　者：陈思娇[1] 王东辉[1] 孙玉强[1] 李廷富[1] 

机构地区：[1]中国医科大学附属第一医院老年病教研室,110001

出　　处：《中国老年保健医学》2006年第4期21-22,共2页Chinese Journal of Geriatric Care

摘　　要：目的探讨慢性心力衰竭(CHF)患者肾素-血管紧张素-醛固酮系统(RAAS)的活性。方法采用放免法测定不同血压CHF患者A组(SBP>13.33kPa)22例、B组(SBP<13.33kPa)22例及健康对照组C组25例的血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)及血清钠水平。结果A组及B组血浆PRA、AngⅡ和ALD均明显高于对照组C组(P<0.01);A组血清钠、血浆PRA、AngⅡ和ALD高于B组(P<0.01);A组血清钠、显著低于B组(P<0.01)。结论CHF患者体内RAAS活性增高,且SBP<13.33kPa者高于SBP>13.33kPa者。objective To explore therenin-angiotensin-aldosterone system (RAAS) activity of patients with congestive heart failure (CHF).Methods 44 patients were divided into two groups ac cording to their systolic blood pressure (SBP):①patients with SBP<13.33kPa(A,n=22);②patients with SBP>13.33kPa (B,n=22).Normal control group incuded 25 health people(C,n=25). Plasm allevel sofrenin, angiotensin and aldosterone activity (PRA,Ang Ⅱ and ALD) were measured by radio-immunityas say (RIA).Results Plasm alevels of PRA, AnglIand ALD in A and B groups were significantly higher than Thosein control group(P<0.01), especially in Agroup (compared with B group,P<0.01).A group had lower serum sodium, SBP and puls epressure/systo licpressure compared with B group(P<0.01). Conclusion RAAS activity llncrease din the CHF patients,especially in the patients with SBP lower than 13.33kPa.

关 键 词：心力衰竭 血压 肾素-血管紧张素-醛固酮系统 

分 类 号：R541.6[医药卫生—心血管疾病]