益寿调脂片对颈动脉硬化症血脂和自由基的干预作用研究  

Intervention effect of Yishou Tiaozhi tablet on free radical and blood fat in carotid atherosclerosis

作　　者：薛铸[1] 郑士富[2] 张荣华[3] 黄荣华[1] 杨烈[1] 胡志兵[1] 朱秉匡[2] 

机构地区：[1]广州市第十二人民医院,广东广州510620 [2]暨南大学华侨医院,广东广州510600 [3]暨南大学,广东广州510600

出　　处：《世界中西医结合杂志》2006年第1期51-53,共3页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的:观察益寿调脂片对颈动脉粥样硬化症血脂、自由基的影响。方法:将90例颈动脉粥样硬化症患者随机分为益寿调脂片组60例和舒降之组30例,观察治疗后血脂、一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)的变化。结果:两组TC、LDL-C、TC／HDL-C、APOB、AI显著下降(P<0．01),APOA、APOA／APOB显著升高(P<0．05),SOD、NO升高和MDA降低(P<0．05)。舒降之组LDL-C下降比益寿调脂片组明显(P<0．05),益寿调脂片组TG、LP(a)下降比舒降之组明显(P<0．05)。结论:益寿调脂片具有降脂、升高SOD、NO,降低MDA的作用。Objectives: To investigate the effect of Yishou Tiaozhi tablet on neck atherosclerosis and free radicals. Methods: 90 patients with atherosclerosis were divided into Yishou Tiaozhi group (60 aptients) and Shujiangzhi (Simvastatine) group (30). The changes of blood fat, NO、SOD and MDA were observed after treatment. Results: In both groups, TC、LDL-C、TC/HDL-C、APOB and AI were distinctly lowered (P <0.01), APOA, APOA, APOB distinctly increased (P<0.05), SOD, NO increased and MDA was lowered (P<0.05). LDL-C in Shujiang zhi group was lowered more than that in Yishou Tiaozhi group (P <0.05), TG、LP (a) in YishouTiaozhi group were lowered more than that in Shujiangzhi (Simvastatine) group. Conclusion: YishouTiaozhi tablet has the functions of lowering fat, enhancing SOD and NO, and lowering MDA.

关 键 词：益寿调脂片 颈动脉硬化症 血脂 一氧化氮 超氧化物歧化酶 丙二醛 

分 类 号：R289.11[医药卫生—方剂学]