抗癫痫新药非氨酯的合成综述  

Synthesis of Felbamate

作　　者：洪梅[1] 陆慧[1] 肖亚平[1] 

机构地区：[1]南京师范大学化学与环境科学学院,江苏南京210097

出　　处：《江苏化工》2006年第6期14-15,19,共3页Jiangsu Chemical Industry

摘　　要：总结抗癫痫新药非氨酯及其重要中间体2-苯基-1,3-丙二醇的各种合成路线,并对各条路线作了评述,从而选出一条适合工业化的路线:以苯乙酸甲酯作原料,依次与甲酸甲酯、硼氢化钠反应生成2-苯基-1,3-丙二醇。该中间体与氨基甲酸甲酯反应制得非氨酯。Felbamate is a new anti-epilepsy drug. The synthetic methods for felbamate and its key intermediate of 2-phenyl-1,3-propanediol were introduced in this paper. Each method was evaluated. Thereby choosing a suitable method for industry: methyl phenyl acetate reacted with methyl formate, then the product reacted with sodium borohydride to obtain 2-phenyl-1,3-propanediol. The intermediate reacted with methyl carbamate to obtain felbamate.

关 键 词：抗癫痫 非氨酯 2-苯基-1 3-丙二醇 合成 

分 类 号：TQ463+4[化学工程—制药化工]